Alprostadil plays a protective role in contrast-induced nephropathy in the elderly
| Autor: | Hong Yan, Beiyun Wang, Yuan Zhong, Ya Miao, Wei Li, Jun Jin |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Iohexol Urology Contrast-induced nephropathy Contrast Media Renal function Risk Assessment Statistics Nonparametric Blood Urea Nitrogen Nephropathy chemistry.chemical_compound Double-Blind Method Reference Values medicine Humans Prospective Studies Alprostadil Cystatin C Infusions Intravenous Prospective cohort study Geriatric Assessment Blood urea nitrogen Aged Aged 80 and over Creatinine biology business.industry Age Factors Acute Kidney Injury medicine.disease Primary Prevention Treatment Outcome chemistry Nephrology Anesthesia Concomitant biology.protein Urological Agents Female Tomography X-Ray Computed business Follow-Up Studies |
| Zdroj: | International Urology and Nephrology. 45:1179-1185 |
| ISSN: | 1573-2584 0301-1623 |
| Popis: | To evaluate the protective effects of alprostadil on contrast-induced nephropathy (CIN) in elderly patients. We randomized 370 patients into the control or alprostadil group. The patients in the control group were injected with 100 ml sterile saline and the patients in the alprostadil group with alprostadil (0.4 μg/kg/day) in 100 ml sterile saline before and after iohexol-enhanced (100 ml) computed tomography (CT). Serum creatinine (Scr), blood urea nitrogen (BUN), cystatin C (CysC), and creatinine clearance (Ccr) were analyzed or calculated. ΔScr and ΔCysC were determined by the changes between baseline and highest Scr and CysC levels. The standard for CIN was a postdose Scr increase >44.2 μmol/l or >25 % over baseline. In the control group, peak Scr (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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