Matrix Metalloproteinases MMP-1 and MMP-9 and Their Inhibitor TIMP-1 as Markers of Dilated Cardiomyopathy in Patients of Different Age
| Autor: | I. B. Antonov, Natalia Linkova, K. L. Kozlov, O. V. Polyakova, E. M. Paltseva |
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| Rok vydání: | 2018 |
| Předmět: |
Cardiomyopathy
Dilated Male Pathology medicine.medical_specialty Primary Cell Culture Cardiomyopathy Autopsy 030204 cardiovascular system & hematology Matrix metalloproteinase General Biochemistry Genetics and Molecular Biology Pathogenesis Extracellular matrix 03 medical and health sciences 0302 clinical medicine medicine Humans Myocytes Cardiac In patient Aged Aged 80 and over Tissue Inhibitor of Metalloproteinase-1 business.industry Myocardium Age Factors Dilated cardiomyopathy General Medicine Middle Aged medicine.disease Extracellular Matrix Matrix Metalloproteinase 9 Case-Control Studies 030220 oncology & carcinogenesis Matrix Metalloproteinase 2 business Biomarkers |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 164:550-553 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-018-4030-0 |
| Popis: | We studied the expression of MMP-2, MMP-9, and inhibitor TIMP-1 in myocardial autopsy samples from subjects of different age and in cardiomyocyte cultures in the norm and in dilated cardiomyopathy. In autopsy samples of normal myocardium and in cardiomyocyte cultures, expression of molecules involved in extracellular matrix remodeling did not change during aging. In dilation cardiomyopathy, expression of MMP-2, MMP-9, and TIMP-1 and their ratios in autopsy material and in cultures was elevated by 1.5-9 times. Remodeling of extracellular matrix plays an important role in the pathogenesis of dilated cardiomyopathy. MMP-2, MMP-9, and their inhibitor TIMP-1 and the MMP/TIMP ratios can be regarded as promising predictors of dilated cardiomyopathy and used for evaluation of the effectiveness of treatment of this conditions in patients of different ages. |
| Databáze: | OpenAIRE |
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