The discriminative stimulus properties of ethanol and acute ethanol withdrawal states in rats
| Autor: | Richard D. Harland, Ron C. Michaelis, Jose R. Criado, Frank A. Holloway, David V. Gauvin |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Alcohol Drinking medicine.drug_class Stimulus (physiology) Pharmacology Toxicology Anxiolytic Choice Behavior Generalization Psychological Chlordiazepoxide Psychoses Alcoholic Alcohol Withdrawal Delirium Drug withdrawal Alcohol intoxication medicine Animals Pharmacology (medical) Pentylenetetrazol Dose-Response Relationship Drug Rats Inbred Strains medicine.disease Rats Psychiatry and Mental health Affect Anxiogenic Anesthesia Pentylenetetrazole Cues Stimulus control Psychology Arousal Alcoholic Intoxication medicine.drug |
| Zdroj: | Drug and alcohol dependence. 24(2) |
| ISSN: | 0376-8716 |
| Popis: | Twelve male Sprague-Dawley rats were trained in a standard two-choice Drug 1-Drug 2 discrimination task utilizing 3.0 mg/kg chlordiazepoxide (CDP, an anxiolytic drug) and 20 mg/kg pentylenetetrazol (PTZ, an anxiogenic drug) as discriminative stimuli under a VR 5–15 schedule of food reinforcement. Saline tests conducted at specific time points after acute high doses of ethanol (3.0 and 4.0 g/kg) indicated a delayed rebound effect, evidenced by a shift to PTZ-appropriate responding. Insofar as such a shift in lever selection indexes a delayed anxiety-like state, this acute ‘withdrawal’ reaction can be said to induce an affective state similar to that seen with chronic ethanol withdrawal states. Ethanol generalization tests:1 resulted in a dose-and time-dependent biphasic generalization to CDP, (2) failed to block the PTZ stimulus and (3) failed to block the time- and dose-dependent elicitation of an ethanol-rebound effect. These data suggest that ethanol's anxiolytic effects are tenuous. |
| Databáze: | OpenAIRE |
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