Oxygen toxicity in the nervous tissue: Comparison of the antioxidant defense of rat brain and sciatic nerve
| Autor: | Francisco J. Puertas, Carlos Hermenegildo, Joaquín Romá, Juan Segura-Aguilar, Elena Monsalve, Eberhard Nies, Francisco J. Romero, Victoria Higueras |
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| Rok vydání: | 1991 |
| Předmět: |
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Central nervous system Pharmacology medicine.disease_cause Biochemistry Antioxidants Cellular and Molecular Neuroscience chemistry.chemical_compound NAD(P)H Dehydrogenase (Quinone) medicine Animals Quinone Reductases Oxygen toxicity Glutathione Peroxidase Superoxide Dismutase Chemistry Nervous tissue Brain Rats Inbred Strains General Medicine Glutathione medicine.disease Sciatic Nerve Rats Oxygen tension Oxygen medicine.anatomical_structure Peripheral nervous system Sciatic nerve Oxidative stress |
| Zdroj: | Neurochemical Research. 16:157-161 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/bf00965704 |
| Popis: | Nervous tissue, central and peripheral, is, as any other, subject to variations in oxygen tension, and to the attack of different xenobiotics; these situations may promote the generation of activated oxygen species of free radical character. Results are presented showing that the content of total glutathione (GSH) in brain is 10-fold that found in the sciatic nerve of the rat (2620 vs. 261 nmol/g wet weight, respectively). The existence of a relatively high superoxide dismutase activity in peripheral nervous tissue, when compared with brain or liver, in combination with the DT-diaphorase activity detected in the sciatic nerve might represent an effective defense mechanism against quinone toxicity, as is also discussed. Nervous tissue, both central and peripheral lack Se-independent GSH peroxidase activity. Finally, the activities of other glutathione-related enzymes studied in the sciatic nerve are very low, when compared with the central nervous tissue, thus suggesting a higher susceptibility of peripheral tissue to oxidative stress damage, since GSH concentration and/or any GSH-related enzymatic activities, e.g. GSH peroxidase or glutathione disulfide reductase, might become limiting. |
| Databáze: | OpenAIRE |
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