Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study
| Autor: | Marcela Guevara, Vicente Martín, Beatriz Pérez-Gómez, Guillermo Fernández-Tardón, Juan Pablo Barrio Lera, Rocío Capelo, Dora Romaguera, Rocío Olmedo-Requena, Ana Molina-Barceló, Tania Fernández-Villa, María Rubín-García, Marina Pollán, Raul Zamora-Ros, Victor Moreno, Vasiliki Roussou, Jesús Castilla, Nuria Aragonés, Manolis Kogevinas, Mireia Obón-Santacana, Antonio J. Molina, Facundo Vitelli Storelli, Inés Gómez-Acebo, María Dolores Chirlaque |
|---|---|
| Přispěvatelé: | Instituto de Salud Carlos III, Fundación Marqués de Valdecilla, Ministerio de Economía y Competitividad (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), International Cancer Genome Consortium, Red Temática de Investigación Cooperativa en Cáncer (España), Regional Government of Andalusia (España), Generalitat Valenciana (España), Basque Government (España), Gobierno de la Región de Murcia (España), Asociación Española Contra el Cáncer, Agencia de Gestio d'Ajuts Universitaris i de Recerca, Fundación Caja de Ahorros de Asturias, University of Oviedo (España), Universidad de Cantabria, UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología, European Regional Development Fund, Gobierno de Andalucía, Generalitat Valenciana, Gobierno Vasco, Gobierno de Murcia, Fundación Científica AECC, Universidad de Oviedo |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male análisis de alimentos humanos Physiology Logistic regression 0302 clinical medicine Risk Factors flavonoides Epidemiology Odds Ratio heterocyclic compounds Flavonoides mediana edad neoplasias gástricas education.field_of_study anciano Nutrition and Dietetics dieta food and beverages MCC-Spain Case-control study adulto Middle Aged cociente de probabilidades relativas 030220 oncology & carcinogenesis Intake Dieta Female lcsh:Nutrition. Foods and food supply intake Adult medicine.medical_specialty Farmacologia Stomach cancer Medicina case-control study Population estudios de casos y controles Protective factor lcsh:TX341-641 macromolecular substances Article 03 medical and health sciences Stomach Neoplasms Statistical significance medicine factores de riesgo Humans education Aged Pharmacology Flavonoids business.industry Càncer d'estómac gastric cancer fungi Cancer Odds ratio medicine.disease Diet 030104 developmental biology Spain Case-Control Studies business Gastric cancer Food Analysis Food Science |
| Zdroj: | Nutrients r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) Nutrients. 2019 Apr 27;11(5). pii: E967 Biblos-e Archivo. Repositorio Institucional de la UAM instname UCrea Repositorio Abierto de la Universidad de Cantabria Universidad de Cantabria (UC) r-FISABIO. Repositorio Institucional de Producción Científica Nutrients, Vol 11, Iss 5, p 967 (2019) Volume 11 Issue 5 Dipòsit Digital de la UB Universidad de Barcelona Arias Montano. Repositorio Institucional de la Universidad de Huelva Repisalud Instituto de Salud Carlos III (ISCIII) |
| ISSN: | 2072-6643 |
| Popis: | Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be of interest to the research community. We used data from a population-based multi-case control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC cases were included in this study. Odds ratios (ORs) were calculated using the mixed effects logistic regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated with a lower GC risk (ORlog2 = 0.76 95% CI = 0.65&ndash 0.89 ORq4vsq1 = 0.60 95%CI = 0.40&ndash ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins, chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with higher cancer risk, but without reaching a statistical significance. In general, no differences were observed in the GC risk according to the location and histological type. The flavonoid intake seems to be a protective factor against GC within the MCC-study. This effect may vary depending on the flavonoid class but not by the histological type and location of the tumor. Broader studies with larger sample size and greater geographical variability are necessary. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|