Aerobic training activates interleukin 10 for colon anticarcinogenic effects
| Autor: | Sergio Akira Uyemura, Gabriela Pereira-da-Silva, Fernando Tadeu Trevisan Frajacomo, Thais Herrero Geraldino, Vinicius Kannen, Sérgio Britto Garcia, Alceu Afonso Jordão-Jr, Rafael Deminice |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Methylnitronitrosoguanidine medicine.medical_specialty Physical Therapy Sports Therapy and Rehabilitation Physical exercise Pharmacology Mice Physical Conditioning Animal Animals Humans Medicine Aerobic exercise Orthopedics and Sports Medicine Swimming Mice Inbred BALB C Physical conditioning business.industry Resistance training Resistance Training Interleukin-10 Colon carcinogenesis Mice Inbred C57BL Disease Models Animal Interleukin 10 MODELOS ANIMAIS Colonic Neoplasms Carcinogens Physical therapy business Precancerous Conditions |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Physical exercise has been shown to be protective against colon carcinogenesis. Physical exercise, however, covers a wide range of modalities, from which different effects on the human body have been reported. We sought to clarify whether aerobic and resistance trainings would differently affect the development of early carcinogenic events in the colon.Male BALB/c, C57/BL6, and interleukin 10 knockout (IL-10; on C57/BL6 background) mice were exposed to the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine. BALB/c mice were subjected to either aerobic (swimming) or resistance trainings (climbing a ladder with load attached to the tail). C57/BL6 and IL-10 mice only swam.In BALB/c carcinogen-exposed mice, aerobic and resistance trainings decreased serum creatine kinase levels (P0.001). Although aerobic and resistance trainings reduced the generation of lipid thiobarbituric reactive species (P0.01 and P0.001), only aerobic exercises enhanced serum glutathione levels aside from carcinogenic exposure (P0.05). Carcinogen-exposed and aerobic-trained mice developed 36% less colon preneoplastic lesions than its control group (P0.05). Aerobic training reduced colonic subepithelial cyclooxygenase-2 expression in carcinogen-exposed mice (P0.001). Interestingly, in this same group, colonic IL-10 expression was upregulated sevenfold (P0.001). Current findings were confirmed in C57/BL6 carcinogen-exposed mice, in which aerobic training promoted antipreneoplastic effects (P0.05). Knocking IL-10 out of C57/BL6 mice abrogated antipreneoplastic effects of aerobic training on the colon tissue (P0.05).IL-10 is a pivotal element for antipreneoplastic effects of aerobic training on the colon. |
| Databáze: | OpenAIRE |
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