On-line enantioseparation of chlorpheniramine using -cyclodextrin and carbon nanotubes after multivariate optimization
| Autor: | Liliana Patricia Fernandez, Raúl A. Gil, Roxana A. Gómez, Raúl Alejandro Silva, Gimena Acosta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Flow injection analysis Chlorpheniramine Chromatography Cyclodextrin Chemistry ON-LINE ENANTIORESOLUTION beta-Cyclodextrins B-CICLODEXTRIN Ciencias Químicas Stereoisomerism Carbon nanotube Multivariate optimization CARBON NANOTUBES Analytical Chemistry law.invention Spectrometry Fluorescence law MULTIVARIATE OPTIMIZATION FLOW INJECTION ANALYSIS Multivariate Analysis Química Analítica Line (text file) CIENCIAS NATURALES Y EXACTAS |
| Popis: | Multiwalled carbon nanotubes are evaluated here as solid phase extraction (SPE) sorbent aiming to (±)-chlorpheniramine (CPA) enantioresolution with fluorimetric detection. β-cyclodextrin (CD) was added to the racemate and solutions with HCl and sodium dodecyl sulfate (SDS) in different proportions were assayed as eluents to achieve the separation between both enantiomers. The overall methodology involved a flow injection (FI) strategy enabling high sample throughput and low reagents consumption making it suitable for drug routine quality control. An adequate enantioresolution (2.08) with satisfactory responses for both (R)-CPA (peak area = 285) and (S)-CPA (peak area = 380) was achieved applying the proposed FI-SPE strategy under the optimized conditions [β-CD] = 1.0 mmol L-1, [HCl] = 1.0 x 10-2 mol L-1, [SDS] = 4.0 x 10-4 mol L-1 and eluent flow rate = 8.0 rpm. Fil: Acosta, Gimena. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - San Luis. Instituto de Quimica de San Luis; Argentina Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina Fil: Gil, Raul Andres. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina Fil: Gomez, Roxana. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Fil: Fernandez, Liliana Patricia. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - San Luis. Instituto de Quimica de San Luis; Argentina |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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