Alternative splicing of the βA4 amyloid gene of Alzheimer's disease in cortex of control and Alzheimer's disease patients
| Autor: | Schmitt Hp, J.M. Salbaum, Lang W, Colin L. Masters, G. König, Wiestler O, Konrad Beyreuther |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Aging Amyloid RNA Splicing Cellular and Molecular Neuroscience Alzheimer Disease Reference Values mental disorders Amyloid precursor protein medicine Humans Molecular Biology Gene Aged Aged 80 and over Cerebral Cortex Amyloid beta-Peptides biology Single-Strand Specific DNA and RNA Endonucleases Alternative splicing Human brain Middle Aged medicine.disease medicine.anatomical_structure Cerebral cortex RNA splicing biology.protein Cancer research Alzheimer's disease Neuroscience |
| Zdroj: | Molecular Brain Research. 9:259-262 |
| ISSN: | 0169-328X |
| DOI: | 10.1016/0169-328x(91)90010-u |
| Popis: | An S1 nuclease protection assay was designed to study the splicing pattern of the alternatively spliced βA4 amyloid gene (APP gene) of Alzheimer's disease (AD). We determined the splicing pattern of the APP gene in fetal, adult, aged adult and AD human cortex. The results suggest that alternative splicing of the APP gene in AD is not significantly different from age-matched controls, but distinct from the developing fetal brain. |
| Databáze: | OpenAIRE |
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