Historical control background incidence of spontaneous thyroid and parathyroid glands lesions of rats and CD-1 mice used in 104-week carcinogenicity studies
| Autor: | Alys Bradley, Claudio Petterino, Sydney Mukaratirwa, Kaori Isobe |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Adenoma Short Communication Distension Toxicology Follicular cell parathyroid gland Pathology and Forensic Medicine 03 medical and health sciences Follicular phase Medicine Cyst Han-Wistar thyroid gland business.industry 030111 toxicology Thyroid carcinogenicity studies Hyperplasia medicine.disease medicine.anatomical_structure Parathyroid gland Sprague-Dawley business CD-1 |
| Zdroj: | Journal of Toxicologic Pathology |
| ISSN: | 0914-9198 |
| Popis: | The incidence and range of spontaneous thyroid and parathyroid glands findings were determined in control Han-Wistar and Sprague-Dawley rats, and CD-1 mice from 104-week carcinogenicity studies carried out between 1998 and 2010 at Charles River Edinburgh. In both strains of rats and in CD-1 mice, non-proliferative lesions of the thyroid or parathyroid glands were generally uncommon apart from some findings in CD-1 mice such as ultimobranchial duct/cyst (5.72%), follicular distension/dilatation (3.84%), and cystic follicles (3.53%). In Han-Wistar rats, thyroid proliferative lesions were slightly more frequent in males than in females, but in Sprague-Dawley rats, they were of similar incidence in both sexes. The most common findings overall in Han-Wistar and Sprague-Dawley rats were C-cell hyperplasia (48.11% and 36.56%, respectively) and adenoma (10.87% and 9.52%, respectively), follicular cell hyperplasia (4.21% and 0.91%, respectively) and adenoma (4.32% and 1.36%, respectively). Secondary neoplastic lesions either in thyroid or parathyroid gland were poorly represented. |
| Databáze: | OpenAIRE |
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