Evaluation of the Immunomodulatory Effects of Fucoidan Derived from Cladosiphon Okamuranus Tokida in Mice
| Autor: | Masahiko Iha, Takeaki Nagamine, Tomofumi Miyamoto, Makoto Tomori |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
Cladosiphon okamuranus Pharmaceutical Science Immunoglobulin E 01 natural sciences Microbiology 03 medical and health sciences chemistry.chemical_compound Immune system fucoidan Drug Discovery medicine Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 immunomodulatory 030304 developmental biology immune cell proliferation 0303 health sciences biology 010405 organic chemistry Fucoidan Interleukin 0104 chemical sciences Cytokine chemistry lcsh:Biology (General) Humoral immunity biology.protein Antibody |
| Zdroj: | Marine Drugs, Vol 17, Iss 10, p 547 (2019) Marine Drugs Volume 17 Issue 10 |
| ISSN: | 1660-3397 |
| Popis: | Okinawa mozuku (Cladosiphon okamuranus Tokida) is an edible seaweed classified as brown algae and is a native species of the Ryukyu Islands in Japan. In recent years, the genomic decoding of Okinawa mozuku has been completed. Previous studies on the anti-inflammatory, antiviral, and antitumor properties of Okinawa mozuku have suggested that it affects the regulation of cellular and humoral immunity. The aim of the present study was to examine the immunoregulatory effect of fucoidan derived from Okinawa mozuku in mice. A product containing fucoidan (purity, 88.3% molecular weight, 49.8 kDa) was developed from Okinawa mozuku and tested for its immunoregulatory effects in mice. The experimental animals were 8-week-old female BALB/c mice to which fucoidan (0, 102.5, 205.0, 410.0, and 1025.0 mg/kg) was administered orally continuously for six weeks. Immune cell proliferation, cytokine production, macrophage phagocytosis, and serum antibody concentration were measured. We found that immune cell proliferation, interleukin (IL)-2, macrophage phagocytes, and serum antibodies (IgM, -G, -A) increased significantly, but IL-4, -5, and IgE decreased significantly. These results indicated that fucoidan modulated cellular and humoral immunity. |
| Databáze: | OpenAIRE |
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