The MonoPrep Pap Test for the Detection of Cervical Cancer and Its Precursors
| Autor: | Ann T. Moriarty, Michael R. Henry, Carol C. Eisenhut, R. Marshall Austin, Roosevelt Torno, Lynda Rushing, Todd A. Alonzo, J. Thomas Molina, Sally D. Slowman, Michael D. Glant, David R. Bolick, Edmund S. Cibas |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Adolescent Uterine Cervical Neoplasms Vial Specimen Handling Cancer screening medicine Humans Pap test False Negative Reactions Aged Aged 80 and over Vaginal Smears Cervical cancer medicine.diagnostic_test business.industry Cancer General Medicine Papanicolaou Test Middle Aged Uterine Cervical Dysplasia medicine.disease Squamous intraepithelial lesion Specimen collection Female Radiology business Precancerous Conditions |
| Zdroj: | American Journal of Clinical Pathology. 129:193-201 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1309/e63pqjjxwcdlwnhq |
| Popis: | The MonoPrep Pap Test (MPPT; MonoGen, Lincolnshire, IL) is a novel, liquid-based specimen collection and processing technology for cytologic and molecular testing. Its usefulness in the detection of cervical cancer and its precursors was evaluated in a multicenter, masked, adjudicated, split-sample study of 10,739 samples. After preparation of a conventional smear, the residuum on the collection device was rinsed into a collection vial from which an MPPT slide was prepared. Accuracy was assessed by masked reference interpretation by an independent pathologist. Slides prepared by MPPT, compared with smears, yielded statistically significant increases in relative sensitivity for atypical squamous cells of undetermined significance and worse, atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion/atypical glandular cells and worse, and low-grade squamous intraepithelial lesion and worse. There was no significant difference in relative specificity. MPPT provided a 58% reduction in unsatisfactory slides. There was no significant difference in the presentation of endocervical/transformation zone component or the detection of benign conditions. The MPPT is a promising new liquid-based technology for cervical cancer screening. |
| Databáze: | OpenAIRE |
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