Clinical utility of different approaches for detection of late pseudoprogression in glioblastoma with O-(2-[18F]fluoroethyl)-L-tyrosine PET
| Autor: | Thomas Linsenmann, Camelia M. Monoranu, Milena I Mihovilovic, Almuth F. Kessler, Philipp T. Meyer, Olivia Kertels, Johannes Tran-Gia, Constantin Lapa, Malte Kircher, Joachim Brumberg, Mario Löhr, Ralf-Ingo Ernestus, Samuel Samnick |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty computer.software_genre 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult 0302 clinical medicine Text mining Voxel Positron Emission Tomography Computed Tomography 18F-fluoroethyl-L-tyrosine medicine Humans Radiology Nuclear Medicine and imaging ddc:610 Pseudoprogression Aged Retrospective Studies Receiver operating characteristic business.industry Brain Neoplasms Chemistry Retrospective cohort study General Medicine Middle Aged medicine.disease ROC Curve Tumor progression 030220 oncology & carcinogenesis Disease Progression Cancer research Tyrosine Histopathology Female Radiology business Glioblastoma computer |
| Popis: | PET/CT using O-(2-[F]fluoroethyl)-L-tyrosine (F-FET) has proven valuable in differentiating tumor recurrence and progression from therapy-induced changes. This study aimed to investigate the diagnostic performance of several analytic approaches in the setting of suspected late pseudoprogression (PsP) in glioblastoma multiforme (GBM).Retrospective analysis of tumor recurrence was performed in 36 patients with histopathologically confirmed GBM and suspicion of recurrence/disease progression more than 12 weeks from cessation of irradiation based on MRI and Response Assessment in Neuro-Oncology working group criteria. For differentiation of late PsP from true tumor recurrence, images were analyzed semiquantitatively employing tumor-to-brain ratios using 5 different approaches for tumor and normal brain reference region definition, respectively. Histopathology and/or clinical and imaging follow-up served as reference. Respective areas under the receiver operating characteristic curve were compared.F-FET PET was able to reliably differentiate PsP from true tumor progression with areas under the receiver operating characteristic curve ranging from 0.80 to 0.88 (all P0.01). Irrespective of the approach chosen, the classification differences between the applied methods were not significant (all P0.05), albeit approaches focusing on voxels with the highest uptake tended to perform superior.Irrespective of the analytical approach, F-FET PET is a robust tool for detection of late PsP with only minor differences between different analytical approaches. However, methodological standardization and harmonization are needed to ensure comparability between different centers. |
| Databáze: | OpenAIRE |
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