Regenerative capacity in the lamprey spinal cord is not altered after a repeated transection

Autor: Eduardo Guadarrama, Scott R. Allen, Jennifer R. Morgan, Kendra L. Hanslik, Stephanie M. Fogerson, Tessa L. Harkenrider
Rok vydání: 2019
Předmět:
0301 basic medicine
Nervous system
Physiology
Cellular differentiation
Nervous System
Synapse
Nerve Fibers
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
Morphogenesis
Lamprey spinal cord
Axon
Neurons
Multidisciplinary
Eukaryota
Lampreys
Vertebrate
Agnatha
Electrophysiology
medicine.anatomical_structure
Spinal Cord
Vertebrates
Medicine
Anatomy
Cellular Types
medicine.symptom
Research Article
Reoperation
Spinal Cord Regeneration
Science
Neurophysiology
Biology
Lesion
03 medical and health sciences
biology.animal
Tissue Repair
Cyclostomata
medicine
Animals
Regeneration
Swimming
Spinal Cord Injuries
Biological Locomotion
Lamprey
Regeneration (biology)
Organisms
Biology and Life Sciences
Cell Biology
Recovery of Function
biology.organism_classification
Spinal cord
Axons
Neuroanatomy
Fish
030104 developmental biology
nervous system
Cellular Neuroscience
Synapses
Physiological Processes
Organism Development
Neuroscience
030217 neurology & neurosurgery
Developmental Biology
Zdroj: PLoS ONE, Vol 14, Iss 1, p e0204193 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: The resilience of regeneration in vertebrate tissues is not well understood. Yet understanding how well tissues can regenerate after repeated insults, and identifying any limitations, is an important step towards elucidating the underlying mechanisms of tissue plasticity. This is particularly challenging in tissues such as the nervous system, which contain a large number of terminally differentiated cells (i.e. neurons) and that often exhibits limited regenerative potential in the first place. However, unlike mammals that exhibit very little spinal cord regeneration, many non-mammalian vertebrate species, including lampreys, fishes, amphibians and reptiles, regenerate their spinal cords and functionally recover even after a complete spinal cord transection. It is well established that lampreys undergo full functional recovery of swimming behaviors after a single spinal cord transection, which is accompanied by tissue repair at the lesion as well as axon and synapse regeneration. Here, using the lamprey model, we begin to explore resilience of spinal cord regeneration after a second spinal re-transection. We report that by all functional and anatomical measures tested, the lampreys regenerated after spinal re-transection just as robustly as after single transections. Recovery of swimming behaviors, axon regeneration, synapse and cytoskeletal distributions, and neuronal survival were nearly identical after a single spinal transection or a repeated transection. Thus, regenerative potential in the lamprey spinal cord is largely unaffected by spinal re-transection, indicating a greater persistent regenerative potential than exists in some other highly-regenerative models. These findings establish a new path for uncovering pro-regenerative targets that could be deployed in non-regenerative conditions.
Databáze: OpenAIRE
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