Factors Associated With Treatment Outcome in Patients With Nontuberculous Mycobacterial Pulmonary Disease: a Large Population-based Retrospective Cohort Study in Shanghai
| Autor: | Hai Lou, Shan Hao Chen, Wei Sha, Li Ping Cheng, Qin Sun, Xiao Na Shen, Xu Wei Gui, Jie Cao |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
General Immunology and Microbiology business.industry Treatment outcome Public Health Environmental and Occupational Health Large population Pulmonary disease Retrospective cohort study bacterial infections and mycoses Infectious Diseases Internal medicine bacteria Medicine In patient nontuberculous mycobacteria lung disease risk factors treatment outcome business |
| Zdroj: | Tropical Medicine and Infectious Disease; Volume 7; Issue 2; Pages: 27 |
| DOI: | 10.21203/rs.3.rs-889319/v1 |
| Popis: | Background: Investigate factors associated with treatment outcome in patients with nontuberculous mycobacterial pulmonary disease (NTMPD). Methods: This retrospective cohort study examined NTMPD patients in Shanghai from January 2014 to December 2018. The distribution and incidence of the different causative species were determined. The outcomes of patients infected with different NTM species were compared. Univariate and multivariate binary logistic regression analyses were used to determine the odds ratios (ORs) and 95% confidence intervals (CIs) for the association of different factors with treatment failure. Results: The most common species were Mycobacterium avium complex (MAC) (50%), M. abscessus (28%), and M. kansasii (15%). Over five years, the proportions of M. kansasii and M. abscessus increased, and that of MAC decreased. The treatment success rate was significantly greater for patients infected with M. kansasii (89.9%) than MAC (65.0%, PM. abscessus (36.1%, PM. abscessus: aOR=9.355, P<0.001; MAC: aOR=2.970, P=0.021), having an elevated ESR (>60mm/h: aOR=2.658, P P<0.001), middle-aged and elderly (>60 years-old: aOR=1.739, P=0.021; 45–60 years-old: aOR=1.661, P=0.034). Conclusions: The main bacterial species responsible for NTMPD infections in Shanghai were MAC, M. abscessus, and M. kansasii. Patients with M. kansasii infections had a higher rate of treatment success. Multiple factors including infection by M. abscessu or MAC, an elevated ESR, receiving retreatment, middle-aged and elderly were associated with treatment failure. |
| Databáze: | OpenAIRE |
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