Effect of Dietary Amino Acids, Casein, and Soybean Trypsin Inhibitor on Pancreatic Protein Secretion in Rats
| Autor: | Linda B. Smith, Ingrid Chang, Richard L. Lyman, Barbara Olds Schneeman |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Phenylalanine Medicine (miscellaneous) Pancreatic Juice Casein medicine Animals Amino Acids Intestinal Mucosa Pancreas chemistry.chemical_classification Nutrition and Dietetics Kunitz STI protease inhibitor Chemistry Tryptophan Caseins Proteins Rats Amino acid Enzyme medicine.anatomical_structure Biochemistry Pancreatic juice Dietary Proteins Trypsin Inhibitor Kunitz Soybean Trypsin Inhibitors |
| Zdroj: | The Journal of Nutrition. 107:281-288 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/107.2.281 |
| Popis: | Pancreatic enzyme output in response to various purified diets was studied in rats surgically prepared so that pancreatic secretion could be continuously collected, assayed and returned to the intestine. Intraduodenal infusion of phenylalanine and tryptophan alone did not stimulate secretion. Diets containing phenylalanine, tryptophan, a mixture of amino acids, or hydroxyzed casein, fed intragastrically, evoked a small pancreatic response that was similar to the response to a protein-free diet. intragastric infusion of a diet containing 18% casein stimulated a large initial secretion of enzyme that remained elevated throughout the 5.5 hour experiment. Addition of soybean trypsin inhibitor (SBTI) to the diet increased the pancreatic response over that due to dietary casein alone. When pancreatic juice was diverted from the intestine, the large pancreatic responses to casein or to casein + SBTI were greatly reduced and the response was similar to that of the protein-free diet. |
| Databáze: | OpenAIRE |
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