Gut Barrier Dysfunction Induced by Aggressive Fluid Resuscitation in Severe Acute Pancreatitis is Alleviated by Necroptosis Inhibition in Rats
| Autor: | Wen-Jing Yang, Yun-Sheng Li, Bao-long Yuan, Wenqi Huang, Yu-Ke Xiang, Jian-Tong Shen, Shi-Hong Wen, Yi-Hong Ling, Ke-Xuan Liu, Qing-Rui Cui |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Resuscitation Necroptosis 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Gastroenterology Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Intestinal Mucosa Gut barrier Intestinal ischemia business.industry 030208 emergency & critical care medicine medicine.disease Rats Systemic inflammatory response syndrome medicine.anatomical_structure Pancreatitis Reperfusion Injury Emergency Medicine Acute pancreatitis Pancreas Multiple organ dysfunction syndrome business |
| Zdroj: | Shock. 52:e107-e116 |
| ISSN: | 1540-0514 1073-2322 |
| DOI: | 10.1097/shk.0000000000001304 |
| Popis: | Fluid resuscitation is the first-line antishock treatment in severe acute pancreatitis (SAP). Currently, although mentions of complications related to aggressive fluid resuscitation are very frequent, a lack of proper handling of complications remains. One of the most important complications is intestinal barrier injury, including intestinal ischemia-reperfusion injury following aggressive fluid resuscitation. Once injured, the intestinal barrier may serve as the source of additional diseases, including systemic inflammatory response syndrome and multiple organ dysfunction syndrome, which aggravate SAP. This study focused on the underlying mechanisms of gut barrier dysfunction in rats induced by aggressive fluid resuscitation in SAP. This study further indicated the important role of necroptosis in intestinal barrier injury which could be relieved by using necroptosis-specific inhibitor Nec-1 before aggressive fluid resuscitation, thus reducing intestinal barrier damage. We also found pancreas damage after intestinal ischemia/reperfusion challenge and indicated the effects of high mobility group protein B1 in the vicious cycle between SAP and intestinal barrier damage. |
| Databáze: | OpenAIRE |
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