Asthma is associated with enhanced thrombin formation and impaired fibrinolysis

Autor:	Lech Zareba, Anetta Undas, Lucyna Mastalerz, Coenraad Hemker, Agnieszka Cybulska, Grazyna Pulka, Teresa Iwaniec, Michal Zabczyk, Stanisława Bazan-Socha, Romy Kremers
Přispěvatelé:	Promovendi CD, RS: CARIM - R1.01 - Blood proteins & engineering
Rok vydání:	2016
Předmět:	Male medicine.medical_specialty Allergy medicine.medical_treatment clot lysis time Immunology Comorbidity 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Thrombin Risk Factors Internal medicine Fibrinolysis Odds Ratio medicine Humans Immunology and Allergy Blood Coagulation thrombosis Blood coagulation test Asthma Diagnostic Tests Routine business.industry Middle Aged asthma medicine.disease Thrombosis Endocrinology 030228 respiratory system Coagulation Case-Control Studies thrombin generation Female Blood Coagulation Tests business Plasminogen activator medicine.drug
Zdroj:	Clinical and Experimental Allergy, 46(7), 932-944. Wiley-Blackwell
ISSN:	0954-7894
DOI:	10.1111/cea.12734
Popis:	Background There is evidence that altered blood coagulation and fibrinolysis are involved in the pathogenesis of asthma. Increased thromboembolic risk has been reported in asthmatics. Objective To investigate whether enhanced thrombin generation and impaired fibrinolysis occur in asthmatics. Methods Plasma thrombin generation profile together with a computational assessment of thrombin dynamics and fibrinolytic capacity expressed as clot lysis time (CLT) were determined in 164 consecutive patients with stable asthma and 72 controls matched for age, gender, weight and smoking. Results Asthma patients had 20.2% increased endogenous thrombin potential (ETP), 41.4% higher peak thrombin concentration, 61% higher maximal prothrombin conversion rate, 15.5% faster rate of thrombin formation (all, P < 0.0001) and 10% lower thrombin decay capacity (P = 0.0004) compared with controls. Asthmatics had also 14.4% longer CLT (P = 0.001) associated with 21.3% higher plasminogen activator inhibitor‐1 (PAI‐1) (P < 0.0001), and 13% higher plasma α2‐macroglobulin (P = 0.0002). Using ETP and CLT above 75th percentile of the control values as the cut‐off levels, we found increased risks of enhanced thrombin generation and hypofibrinolysis in asthmatics, also after correction for potential confounders. ETP and CLT were associated inversely with forced expiratory volume in 1 s/vital capacity (FEV1/VC) index, after adjustment for age and body mass index. Non‐allergic asthma (n = 70, 42.6%) was characterized by 17.5% longer CLT (P = 0.02), which positively associated with PAI‐1. Thrombin generation profile was not affected by allergy. Conclusion and Clinical Relevance Asthma is associated with enhanced thrombin generation and impaired fibrinolysis, which might contribute to thromboembolic events in this disease.
Databáze:	OpenAIRE
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