Morphological and chemical analysis of a deep brain stimulation electrode explanted from a dystonic patient
| Autor: | Davide Marchesi, Gero Bongiorno, Luca Ravagnan, Giovanna Zorzi, Giuseppe Messina, Angelo Franzini, Carlo Efisio Marras, Alessandro De Benedictis, Roberto Cordella, Michele Rizzi |
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| Rok vydání: | 2012 |
| Předmět: |
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Reoperation medicine.medical_specialty Materials science Deep brain stimulation Scanning electron microscope medicine.medical_treatment Deep Brain Stimulation Young Adult Deep brain stimulation electrode medicine Electric Impedance Effective treatment Humans Biological Psychiatry Dystonia Sem analysis medicine.disease Surgery Electrodes Implanted Equipment Failure Analysis Psychiatry and Mental health Neurology Dystonic Disorders Electrode Microscopy Electron Scanning Equipment Failure Neurology (clinical) Dystonic disorder Biomedical engineering |
| Zdroj: | Journal of neural transmission (Vienna, Austria : 1996). 120(10) |
| ISSN: | 1435-1463 |
| Popis: | Deep brain stimulation is an effective treatment for different types of dystonia; nevertheless dystonic movements could provoke hardware-related complications, including fractures or electrodes displacement. This study focuses on a morphological and structural analysis of a malfunctioning electrode removed from a dystonic patient. In this case, high impedance values and worsening of symptoms were observed. Scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) were performed on the explanted electrode. The qualitative and quantitative data collected from the damaged electrode were compared with a new electrode, used as a control. The SEM analysis of the damaged electrode revealed fissurations and crack-like forms of the outer jacket tubing, degeneration of the internal core and wires stretching. The EDX analysis permitted to appreciate an increase of chemical elements, especially sodium, suggesting an alteration of the electrode-brain interface. This study shows the qualitative and quantitative alterations of a malfunctioning electrode and, to reduce the rate of hardware-related complications, it suggests the development of more reliable polymers. |
| Databáze: | OpenAIRE |
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