Bone loss determined by quantitative ultrasonometry correlates inversely with disease activity in patients with endogenous glucocorticoid excess due to adrenal mass
| Autor: | Libuse Tauchmanovà, A Esposito-del Puente, V. Nuzzo, Riccardo Rossi, Gaetano Lombardi, Claudia Pizzi, Giovanni Lupoli, Francesco Fonderico, A. Del Puente |
|---|---|
| Přispěvatelé: | Tauchmanovà, L., Rossi, R., Nuzzo, V., DEL PUENTE, Antonio, Esposito del Puente, A., Pizzi, C., Fonderico, F., Lupoli, Giovanni, Lombardi, G. |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Bone disease Bone density Endocrinology Diabetes and Metabolism Osteoporosis Adrenal Gland Neoplasms Bone tissue Dexamethasone Body Mass Index Cushing syndrome Absorptiometry Photon Endocrinology Adrenocorticotropic Hormone Bone Density Internal medicine Humans Medicine Cushing Syndrome Glucocorticoids Ultrasonography Subclinical infection Femoral neck business.industry General Medicine Middle Aged medicine.disease medicine.anatomical_structure Female business Glucocorticoid medicine.drug |
| Zdroj: | European Journal of Endocrinology. :241-247 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1450241 |
| Popis: | OBJECTIVE: Glucocorticoid excess is widely recognized as one of the most important causes of bone loss. The mechanism of glucocorticoid-induced osteoporosis is presumably multifactorial, and consists of the loss of organic and non-organic compounds. Efforts have been made to develop simple physical methods for the assessment of bone tissue for the screening of subjects at high risk of osteoporosis, without the use of radioactive sources or ionizing radiation. Quantitative ultrasonometry (QUS) has been suggested as a useful method for monitoring patients undergoing glucocorticoid therapy, which is the most common cause of glucocorticoid excess. QUS appears to detect more structural bone changes than the traditional methods and allows assessment of bone density and elasticity, both characteristics influenced by organic and non-organic bone compounds. However, the use of QUS has not yet been extensively investigated in subjects with endogenous cortisol excess. The aim of this study was to evaluate the usefulness and predictive power of QUS in assessing bone loss in subjects with differing degrees of endogenous cortisol excess due to adrenal mass. DESIGN: Thirty-four patients (20 women and 14 men) aged between 21 and 59 years were evaluated; fifteen (9 women and 6 men; median age, 42 years) were affected by overt Cushing's syndrome (CS) and nineteen (11 women and 8 men; median age, 44 years) by subclinical CS, defined as lacking clinical signs of hormone excess despite the presence of at least two abnormalities in hypothalamic-pituitary-adrenal axis function, as assessed by routine endocrine tests. All women included were eumenorrhoic. METHODS: QUS measurement of amplitude-dependent speed of sound was performed on the 2nd to 5th proximal phalanges of the non-dominant hand using a DBM Sonic 1200R bone profiler (Igea S.r.l, Italy). The results were compared with bone density assessed on lumbar vertebrae (L1-L4) and femoral neck sites by dual-energy X-ray absorptiometry (DEXA). RESULTS: A strongly significant bone loss was detected by finger QUS measurement when the patients were considered either all together or as two subgroups (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|