Synthesis and Evaluation of Artemisinin-Based Hybrid and Dimer Derivatives as Antimelanoma Agents
| Autor: | Maria Camilla Baratto, Bruno Mattia Bizzarri, Silvia Filippi, Rebecca Pogni, Lorenzo Botta, Roberta Meschini, Claudio Zippilli, Raffaele Saladino, Luciano Villanova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
biology
General Chemical Engineering medicine.medical_treatment Dimer Dihydroartemisinin General Chemistry biology.organism_classification Combinatorial chemistry Article Tyrosol Eugenol HeLa chemistry.chemical_compound Chemistry chemistry Artesunate parasitic diseases medicine Curcumin Artemisinin QD1-999 medicine.drug |
| Zdroj: | ACS Omega ACS Omega, Vol 5, Iss 1, Pp 243-251 (2019) |
| ISSN: | 2470-1343 |
| Popis: | A library of hybrid and dimer compounds based on the natural scaffold of artemisinin was synthesized. These derivatives were obtained by coupling of artemisinin derivatives, artesunate, and dihydroartemisinin with a panel of phytochemical compounds. The novel artemisinin-based hybrids and dimers were evaluated for their anticancer activity on a cervical cancer cell line (HeLa) and on three complementary metastatic melanoma cancer cell lines (SK-MEL3, SK-MEL24, and RPMI-7951). Two hybrid compounds obtained by coupling of artesunate with eugenol and tyrosol, and one of the dimer compounds containing curcumin, emerged as the most active and cancer-selective derivatives. |
| Databáze: | OpenAIRE |
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