Hemodynamic responses to visual stimulation in children with sickle cell anemia

Autor: Ping Zou, Russell E. Ware, Chin-Shang Li, Robert J. Ogg, Kathleen J. Helton, Heather M. Conklin, Matthew P. Smeltzer, Amar Gajjar, Winfred C. Wang
Rok vydání: 2011
Předmět:
Male
medicine.medical_specialty
genetic structures
Anemia
Cognitive Neuroscience
Hemodynamics
Anemia
Sickle Cell
Neuropsychological Tests
behavioral disciplines and activities
Article
Behavioral Neuroscience
Cellular and Molecular Neuroscience
Internal medicine
medicine
Image Processing
Computer-Assisted
Humans
Radiology
Nuclear Medicine and imaging
Child
Visual Cortex
medicine.diagnostic_test
Neuropsychology
Wechsler Scales
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Sickle cell anemia
Oxygen
Psychiatry and Mental health
Visual cortex
medicine.anatomical_structure
Neurology
Cerebral blood flow
nervous system
Cerebrovascular Circulation
Cardiology
Female
Neurology (clinical)
Psychology
Functional magnetic resonance imaging
Neuroscience
psychological phenomena and processes
Algorithms
Photic Stimulation
Zdroj: Brain imaging and behavior. 5(4)
ISSN: 1931-7565
Popis: Blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF)-based functional magnetic resonance imaging (fMRI) were used to measure primary visual cortex responses to photic stimulation in 23 children (12.4 ± 0.7 years old) with sickle cell anemia (SCA) and 21 clinical controls (11 ± 1.0 years old). The objectives were to investigate the effect of SCA on detection of brain activation with fMRI and to explore the relationship between fMRI responses and global cognitive function. The BOLD responses were diminished in children with SCA. Clinical indicators of disease severity were greatest in patients without detectable visual cortex activation, but blood hemoglobin concentration and resting CBF were not predictive of BOLD signal amplitude in the SCA patients. Unexpectedly, the BOLD signal amplitude was positively associated (r(s) ≥ 0.8, p ≤ 0.05) with Wechsler Abbreviated Scale of Intelligence scores, suggesting that fMRI may help clarify medical, hemodynamic, and neural factors that mediate adverse effects of SCA on neurocognitive function.
Databáze: OpenAIRE
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