Intensive insulin therapy increases sex hormone-binding globulin in newly diagnosed type 2 diabetic patients
| Autor: | Lirong Li, Xiaomin Hua, Guangyu Gu, Kui Zhang, Guoyu Tong, Wenhuan Feng, Yanjun Sun, Yingjie Zhong, Tianyan Zhang, Hong Huang, Yun Hu, Weimin Wang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Models Biological Body Mass Index chemistry.chemical_compound Endocrinology Insulin resistance Sex hormone-binding globulin Sex Hormone-Binding Globulin Internal medicine Diabetes mellitus medicine Homeostasis Humans Insulin Triglycerides Aged Triglyceride biology business.industry Alanine Transaminase gamma-Glutamyltransferase General Medicine Middle Aged medicine.disease Metformin Postmenopause Diabetes Mellitus Type 2 Liver chemistry Homeostatic model assessment biology.protein Female Liver function Insulin Resistance Waist Circumference business medicine.drug |
| Zdroj: | European Journal of Endocrinology. 170:237-245 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-13-0557 |
| Popis: | ObjectiveMany studies have shown that low sex hormone-binding globulin (SHBG) is associated with insulin resistance, but only few studies have examined how serum SHBG is regulated by insulin in humans. This interventional study aimed to investigate the effect of insulin therapy (IT) on serum SHBG levels in newly diagnosed type 2 diabetic patients.MethodsA total of 80 newly diagnosed type 2 diabetic subjects were enrolled and randomly grouped into a 2-week intensive IT with/without metformin. Serum SHBG, total testosterone, glucose, liver enzymes, lipids, insulin, and C-peptide levels were measured before and after IT.ResultsBefore IT, serum SHBG levels were negatively correlated with BMI, waist circumference (WC), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (γ-GT), triglyceride (TG), fasting insulin, and C-peptide, and homeostatic model assessment of insulin resistance (HOMA-IR), and positively with HDL-C (allPfor trend PPβ=−0.374,P=0.012) and ΔTG (β=−0.380,P=0.020) were independent contributors to the increase in ΔSHBG.ConclusionsIT increases serum SHBG likely through improving insulin resistance and liver function. |
| Databáze: | OpenAIRE |
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