Impact of Powder Properties on the Rheological Behavior of Excipients
Autor: | Aurélien Neveu, Sébastien Depaifve, Bastiaan H.J. Dickhoff, Filip Francqui, Pauline H. M. Janssen |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
business.product_category
Materials science quality by design Flow (psychology) Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Article Agitator 03 medical and health sciences Tableting Pharmacy and materia medica 0302 clinical medicine Rheology Composite material continuous manufacturing excipients tableting die filling powder rheology 021001 nanoscience & nanotechnology Characterization (materials science) RS1-441 Particle-size distribution Die (manufacturing) 0210 nano-technology Material properties business dynamic cohesive index powder flow |
Zdroj: | Pharmaceutics Volume 13 Issue 8 Pharmaceutics, Vol 13, Iss 1198, p 1198 (2021) |
ISSN: | 1999-4923 |
DOI: | 10.3390/pharmaceutics13081198 |
Popis: | With the emergence of quality by design in the pharmaceutical industry, it becomes imperative to gain a deeper mechanistic understanding of factors impacting the flow of a formulation into tableting dies. Many flow characterization techniques are present, but so far only a few have shown to mimic the die filling process successfully. One of the challenges in mimicking the die filling process is the impact of rheological powder behavior as a result of differences in flow field in the feeding frame. In the current study, the rheological behavior was investigated for a wide range of excipients with a wide range of material properties. A new parameter for rheological behavior was introduced, which is a measure for the change in dynamic cohesive index upon changes in flow field. Particle size distribution was identified as a main contributing factor to the rheological behavior of powders. The presence of fines between larger particles turned out to reduce the rheological index, which the authors explain by improved particle separation at more dynamic flow fields. This study also revealed that obtained insights on rheological behavior can be used to optimize agitator settings in a tableting machine. |
Databáze: | OpenAIRE |
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