Dispersive liquid-liquid microextraction based preconcentration of selected pesticides and escitalopram oxalate, haloperidol and olanzapine from wastewater samples prior to determination by GC-MS
| Autor: | Guleda Onkal Engin, Sezgin Bakırdere, Dotse Selali Chormey, Gamze Dalgıç Bozyiğit, Merve Fırat Ayyıldız |
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| Rok vydání: | 2020 |
| Předmět: |
Analyte
Liquid Phase Microextraction 010501 environmental sciences Standard solution Citalopram Wastewater 01 natural sciences Gas Chromatography-Mass Spectrometry Analytical Chemistry chemistry.chemical_compound Limit of Detection Calibration Humans Environmental Chemistry Pesticides 0105 earth and related environmental sciences Detection limit Pharmacology Chloroform Chromatography 010401 analytical chemistry Pesticide 0104 chemical sciences chemistry Olanzapine Haloperidol Gas chromatography–mass spectrometry Agronomy and Crop Science Water Pollutants Chemical Food Science |
| Zdroj: | Journal of AOAC INTERNATIONAL. |
| ISSN: | 1944-7922 1060-3271 |
| DOI: | 10.1093/jaocint/qsaa082 |
| Popis: | Background Determination of emerging pollutants including pharmaceuticals, pesticides, industrial chemicals and hormones in different environmental samples is very important for human health. Objective Experimental design enabled parameters to be evaluated for their effects onextraction output as well as their interactive effects. Method A multivariate experimental design was used to attain optimum conditions of a dispersive liquid-liquid microextraction method for preconcentration of pesticides and pharmaceuticals for determination by GC-MS. Results The optimum parameters suggested by the design model were 200 µL of chloroform, 1.96 mL of ethanol, and 40 s vortexing period. LOD and LOQ were calculated using linear calibration plots of the analytes developed in the standard concentration range of 2.0 μg/L–2.0 mg/L. Conclusions Enhancement in detection power of the analytes recorded by the optimized method with respect to direct GC-MS determination (based on LOD values) was in the range of 3.6 and 539 folds. Spiked recovery experiments for municipal, medical, and synthetic wastewater samples yielded low recovery results when calculated against aqueous standard solutions. Matrix matched calibration standards were used to mitigate interferences from the waste samples and the percent recoveries obtained were close to 100%. This established accuracy and applicability of the developed method. Highlights The detection limits were found between 0.50 ng/mL and 37 ng/mL. An accurate, simple and sensitive analytical method was developed for the analytes. |
| Databáze: | OpenAIRE |
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