Inflammatory and neurodegeneration markers during asymptomatic hsv-1 reactivation
| Autor: | Margarita I. Concha, Karin Vío, Paulina Araya, Sharin Valdivia, Carolina Martin, Angara Zambrano, Blanca Aguila, Carola Otth |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty viruses Context (language use) Herpesvirus 1 Human Biology medicine.disease_cause Asymptomatic Mice Trigeminal ganglion medicine Animals Neuroinflammation Inflammation Mice Inbred BALB C General Neuroscience Neurodegeneration Herpes Simplex Neurodegenerative Diseases General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Herpes simplex virus Cerebral cortex Asymptomatic Diseases Immunology Female Virus Activation Geriatrics and Gerontology medicine.symptom Biomarkers Encephalitis |
| Zdroj: | JOURNAL OF ALZHEIMER`S DISEASE Artículos CONICYT CONICYT Chile instacron:CONICYT |
| Popis: | Background Currently, it is unclear whether asymptomatic recurrent reactivations of herpes simplex virus type 1 (HSV-1) occur in the central nervous systems of infected people, and if these events could lead to a progressive deterioration of neuronal function. In this context, HSV-1 constitutes an important candidate to be included among the risk factors for the development of neuropathies associated with chronic neuroinflammation. Objective The aim of this study was to assess in vivo inflammatory and neurodegenerative markers in the brain during productive and latent HSV-1 infection using a mouse model of herpes simplex encephalitis. Methods Neuroinflammation and neurodegeneration markers were evaluated in mice trigeminal ganglia and cerebral cortex during HSV-1 infection, by immunohistochemistry, western blot, and RT-PCR. Results Neuronal ICP4 viral antigen expression indicative of a reactivation episode during asymptomatic latency of HSV-1 infection in mice was accompanied by upregulation of neuroinflammatory (toll-like receptor-4, interferon α/β, and p-IRF3) and early neurodegenerative markers (phospho-tau and TauC3). Conclusions HSV-1 reactivation from latency induced neuroinflammatory and neurodegenerative markers in the brain of asymptomatic mice suggesting that recurrent reactivations could be associated with cumulative neuronal dysfunctions. |
| Databáze: | OpenAIRE |
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