5-HT(2) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: A PET study
| Autor: | Maria Carla Gilardi, Enrico Smeraldi, Giovanna Rizzo, Francesc Artigas, Ferruccio Fazio, Raffaella Zanardi, L. Galli, Giovanni Lucignani, Rosa Maria Moresco, C. Gobbo, Cristina Colombo, Cristina Messa |
|---|---|
| Přispěvatelé: | Messa, M, Colombo, C, Moresco, R, Gobbo, C, Galli, L, Lucignani, G, Gilardi, M, Rizzo, G, Smeraldi, E, Zanardi, R, Artigas, F, Fazio, F, Messa, C, Colombo, CRISTINA ANNA, Moresco, Rm, Gilardi, Mc, Fazio, F. |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male serotonin receptor Fluorine Radioisotopes Serotonin receptors medicine.medical_specialty Emission tomography Antidepressant Ligands emission tomography Internal medicine serotonin receptors medicine Humans Major depression Receptor Serotonin 5-HT2A 5-HT receptor Pharmacology Depressive Disorder Major antidepressant Receptors Dopamine D2 Brain Middle Aged medicine.disease Paroxetine Pathophysiology Drug-naïve Endocrinology Spiperone Case-Control Studies Receptors Serotonin Antidepressive Agents Second-Generation Dopamine Antagonists Major depressive disorder Female Serotonin Psychology Reuptake inhibitor Selective Serotonin Reuptake Inhibitors Tomography Emission-Computed medicine.drug |
| Zdroj: | 167 (2003): 72–78. info:cnr-pdr/source/autori:Messa C. 1, Colombo C. 1, Moresco R.M. 1, Gobbo C. 1, Galli L. 1, Lucignani G.1, Gilardi M.C. 1, Rizzo G. 1, Smeraldi E. 1, Zanardi R.1, Artigas F. 2, Fazio F. 1/titolo:5-HT(2) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: A PET study/doi:/rivista:/anno:2003/pagina_da:72/pagina_a:78/intervallo_pagine:72–78/volume:167 Scopus-Elsevier Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Cristina Messa et al. [Objective]: The aim of the study was to investigate differences in 5-HT2A receptor binding between healthy volunteers and patients with major depressive disorder (MDD), either never treated before with antidepressants (drug-naive: DN) or responding to paroxetine treatment (drug-treated: DT) [Methods]: Nineteen DN patients with MDD and 15 euthymic DT (paroxetine 4 weeks) patients were compared with a group of 20 healthy controls (C) with positron emission tomography (PET) using [(18)F]fluoroethylspiperone ([(18)F]FESP), a 5-HT(2A) and D(2) receptor antagonist. A "binding index" (BI) of [(18)F]FESP to cortical and basal ganglia regions was calculated as the ratio of the activity in these regions to that of cerebellum. Differences in BI between groups, i.e. C versus DN or DT, were assessed by ANOVA, with or without age as covariate (ANCOVA). [Results]: A significant reduction in BI ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN patients in the frontal, occipital, temporal and cingulate cortices, but not in the striatum. No significant differences emerged between C and DT patients. [Conclusions]: The reduction of [(18)F]FESP BI in cortical areas of DN depressed, but not of euthymic DT patients suggests an association between the occurrence of depressive symptoms and impairment of cortical 5-HT(2A) receptors. [(18)F]FESP cortical BI may represent a state marker of depression. Grant supporting: Fondo de Investigación Sanitaria 98/6978 (profesor Artigás). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|