A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk
| Autor: | So Yeon J. Kong, Yunxia Lu, Heinz Freisling, Krasimira Aleksandrova, Mazda Jenab, Ingrid Ljuslinder, Paula Jakszyn, Hui Zuo, Pagona Lagiou, Rudolf Kaaks, Marie-Christine Boutron-Ruault, Grethe S. Tell, Elio Riboli, Sabina Sieri, Ruth C. Travis, Shu Chun Chuang, J. Ramón Quirós, Miren Dorronsoro, Gianluca Severi, Richard Palmqvist, Salvatore Panico, Eva Ardanaz, Stein Emil Vollset, Bas Bueno-de-Mesquita, Tilman Kühn, María José Sánchez, Kim Overvad, Marc J. Gunter, Nicholas J. Wareham, Øivind Midttun, Antoine Racine, María Dolores Chirlaque, Paolo Vineis, Heiner Boeing, Anne M. May, Rosario Tumino, Elisabete Weiderpass, Mattias Johansson, Kay-Tee Khaw, Amanda J. Cross, Antonia Trichopoulou, Dimitrios Trichopoulos, Per Magne Ueland, Tobias Pischon, Anne Tjønneland, Domenico Palli, Veronika Fedirko |
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| Přispěvatelé: | Aleksandrova, Krasimira, Chuang, Shu Chun, Boeing, Heiner, Zuo, Hui, Tell, Grethe S, Pischon, Tobia, Jenab, Mazda, Bueno de Mesquita, Ba, Vollset, Stein Emil, Midttun, Øivind, Ueland, Per Magne, Fedirko, Veronika, Johansson, Mattia, Weiderpass, Elisabete, Severi, Gianluca, Racine, Antoine, Boutron Ruault, Marie Christine, Kaaks, Rudolf, Kühn, Tilman, Tjønneland, Anne, Overvad, Kim, Quirós, J. Ramón, Jakszyn, Paula, Sánchez, María José, Dorronsoro, Miren, Chirlaque, Maria Dolore, Ardanaz, Eva, Khaw, Kay Tee, Wareham, Nicholas J, Travis, Ruth C, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrio, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, May, Anne M, Palmqvist, Richard, Ljuslinder, Ingrid, Kong, So Yeon J, Freisling, Heinz, Gunter, Marc J, Lu, Yunxia, Cross, Amanda J, Riboli, Elio, Vineis, Paolo |
| Rok vydání: | 2015 |
| Předmět: |
Male
Cancer Research Cellular immunity Helper-Inducer Colorectal cancer T-Lymphocytes Colorectal Neoplasm cancer risk medicine.disease_cause immunology chemistry.chemical_compound analogs and derivatives immune system diseases Tandem Mass Spectrometry Odds Ratio Prospective Studies Prospective cohort study Chromatography Liquid Colonic Neoplasm Immunity Cellular Tumor nutrition in cancer oxidative stress colorectal cancer biological markers inflammation neopterin plasma drug concentration colon immune system rectal carcinoma follow-up colon tumor risk assessment Neopterin T-Lymphocytes Helper-Inducer Middle Aged tumor marker adult biological marker unclassified drug Europe priority journal risk factor Oncology Colonic Neoplasms Biomarker (medicine) Female medicine.symptom Colorectal Neoplasms Case-Control Studie prospective study Human Adult Inflammation cellular immunity 8 dihydroneopterin Sensitivity and Specificity Article Immune system blood medicine Biomarkers Tumor liquid chromatography Humans 8-dihydroneopterin controlled study human 7 8-dihydroneopterin Aged helper cell rectum tumor Rectal Neoplasm Rectal Neoplasms business.industry Immunity case control study medicine.disease major clinical study 7 8 dihydroneopterin Prospective Studie chemistry Case-Control Studies tumor marker Immunology Cancer research tandem mass spectrometry Adult Cellular business Biomarkers Oxidative stress colorectal tumor Chromatography Liquid |
| Zdroj: | Aleksandrova, K; Chuang, S-C; Boeing, H; Zuo, H; Tell, GS; Pischon, T; et al.(2015). A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk.. Journal of the National Cancer Institute, 107(4). doi: 10.1093/jnci/djv010. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4sd016w7 Journal of the National Cancer Institute, 107(4): djv010 Journal of the National Cancer Institute, 107(4). Oxford University Press Aleksandrova, K, Chuang, S-C, Boeing, H, Zuo, H, Tell, G S, Pischon, T, Jenab, M, Bueno-de-Mesquita, B, Vollset, S E, Midttun, Ø, Ueland, P M, Fedirko, V, Johansson, M, Weiderpass, E, Severi, G, Racine, A, Boutron-Ruault, M-C, Kaaks, R, Kühn, T, Tjønneland, A, Overvad, K, Quirós, J R, Jakszyn, P, Sánchez, M-J, Dorronsoro, M, Chirlaque, M-D, Ardanaz, E, Khaw, K-T, Wareham, N J, Travis, R C, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Sieri, S, Tumino, R, Panico, S, May, A M, Palmqvist, R, Ljuslinder, I, Kong, S Y J, Freisling, H, Gunter, M J, Lu, Y, Cross, A J, Riboli, E & Vineis, P 2015, ' A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk ', Journal of the National Cancer Institute, vol. 107, no. 4 . https://doi.org/10.1093/jnci/djv010 |
| ISSN: | 0027-8874 |
| Popis: | Background: Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. Results: After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P difference =. 87) and after excluding case patients diagnosed within the first four follow-up years. Conclusions: These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC. © 2015 The Author. Published by Oxford University Press. All rights reserved. |
| Databáze: | OpenAIRE |
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