Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection?
| Autor: | Nahla E. El-Ashmawy, Kamal M Okasha, Yusuf A. Haggag |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cellular immunity Coronavirus disease 2019 (COVID-19) MAP Kinase Signaling System medicine.medical_treatment Diosmin Bioinformatics Antiviral Agents Article 03 medical and health sciences Hesperidin chemistry.chemical_compound 0302 clinical medicine Immunity Medicine Humans Pandemics business.industry Prophylaxis Heparin SARS-CoV-2 Anti-viral activity Viral entry Anticoagulants COVID-19 General Medicine Venous Thromboembolism Virus Internalization medicine.disease COVID-19 Drug Treatment Treatment 030104 developmental biology chemistry Receptors Virus Drug Therapy Combination Angiotensin-Converting Enzyme 2 business Cytokine storm Cytokine Release Syndrome Adjuvant 030217 neurology & neurosurgery medicine.drug Phytotherapy |
| Zdroj: | Medical Hypotheses |
| ISSN: | 1532-2777 |
| Popis: | SARS-CoV-2 or COVID-19 is representing the major global burden that implicated more than 4.7 million infected cases and 310 thousand deaths worldwide in less than 6 months. The prevalence of this pandemic disease is expected to rise every day. The challenge is to control its rapid spread meanwhile looking for a specific treatment to improve patient outcomes. Hesperidin is a classical herbal medicine used worldwide for a long time with an excellent safety profile. Hesperidin is a well-known herbal medication used as an antioxidant and anti-inflammatory agent. Available shreds of evidence support the promising use of hesperidin in prophylaxis and treatment of COVID 19. Herein, we discuss the possible prophylactic and treatment mechanisms of hesperidin based on previous and recent findings. Hesperidin can block coronavirus from entering host cells through ACE2 receptors which can prevent the infection. Anti-viral activity of hesperidin might constitute a treatment option for COVID-19 through improving host cellular immunity against infection and its good anti-inflammatory activity may help in controlling cytokine storm. Hesperidin mixture with diosmin co-administrated with heparin protect against venous thromboembolism which may prevent disease progression. Based on that, hesperidin might be used as a meaningful prophylactic agent and a promising adjuvant treatment option against SARS-CoV-2 infection. |
| Databáze: | OpenAIRE |
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