Silence of FAM83H-AS1 promotes chemosensitivity of gastric cancer through Wnt/β-catenin signaling pathway
| Autor: | Bing Wang, Guoxin Guan, Danyi Zhao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Wnt/β-catenin signaling pathway medicine.medical_treatment Antineoplastic Agents RM1-950 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Cell Line Tumor medicine Gastric mucosa Humans Gene Silencing Lung cancer Chemosensitivity beta Catenin Aged Pharmacology Cisplatin Chemotherapy business.industry Wnt signaling pathway Cancer Proteins General Medicine medicine.disease FAM83H-AS1 Gene Expression Regulation Neoplastic Wnt Proteins 030104 developmental biology medicine.anatomical_structure Cell culture Drug Resistance Neoplasm 030220 oncology & carcinogenesis Long non-coding RNA Cancer research Female Therapeutics. Pharmacology Fluorouracil Signal transduction business Gastric cancer medicine.drug Signal Transduction |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 125, Iss, Pp 109961-(2020) |
| ISSN: | 1950-6007 |
| Popis: | Gastric cancer (GC) is a malignant tumor originated from the epithelium of gastric mucosa, its incidence is second only to lung cancer in China. Chemotherapy is one of the most effective methods to treat GC, but some patients are insensitive to chemotherapeutic drugs, leading to chemotherapy failure. In this study, the expression of FAM83H-AS1 was up-regulated in GC tissues and cell lines, and was related to differentiation, invasion depth and chemotherapy insensitivity of GC patients. FAM83H-AS1 was high-expressed in chemoresistant GC tissues and cell line (SGC7901/R), and silence of FAM83H-AS1 sensitized SGC7901/R cells to cisplatin (CDDP) and 5-fluorouracil (5-FU). In addition, silence of FAM83H-AS1 could inactivate Wnt/β-catenin signaling pathway in SGC7901/R cells. The activating of Wnt/β-catenin signaling pathway reversed the promoting effect of FAM83H-AS1 silence on chemotherapy sensitivity, which meant Wnt/β-catenin signaling pathway mediated the regulation of FAM83H-AS1 on chemotherapy sensitivity in SGC7901/R cells. In conclusion, FAM83H-AS1 is related with the CDDP and 5-FU insensitivity of GC patients, silence of FAM83H-AS1 promotes chemosensitivity of GC through Wnt/β-catenin signaling pathway. |
| Databáze: | OpenAIRE |
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