The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam Study
| Autor: | Marileen L.P. Portegies, Albert Hofman, Renée F A G de Bruijn, Michiel J. Bos, Oscar H. Franco, Peter J. Koudstaal, M. Arfan Ikram |
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| Přispěvatelé: | Neurology, Epidemiology |
| Rok vydání: | 2015 |
| Předmět: |
Gerontology
Male medicine.medical_specialty Epidemiology Hypercholesterolemia Prevention of dementia Effect Modifier Epidemiologic Rotterdam Study SDG 3 - Good Health and Well-being Internal medicine Diabetes Mellitus Medicine Dementia Humans Population attributable risk Longitudinal Studies Prospective Studies Risk factor Prospective cohort study Health Education Aged Netherlands Medicine(all) business.industry Smoking General Medicine Middle Aged Overweight medicine.disease Causality Risk factors Cardiovascular Diseases Cohort Attributable risk Hypertension Female Preventive Medicine business Risk Reduction Behavior Research Article |
| Zdroj: | BMC Medicine BMC Medicine, 13. BioMed Central Ltd. |
| ISSN: | 1741-7015 |
| Popis: | Background: Cardiovascular factors and low education are important risk factors of dementia. We provide contemporary estimates of the proportion of dementia cases that could be prevented if modifiable risk factors were eliminated, i.e., population attributable risk (PAR). Furthermore, we studied whether the PAR has changed across the last two decades. Methods: We included 7,003 participants of the original cohort (starting in 1990) and 2,953 participants of the extended cohort (starting in 2000) of the Rotterdam Study. Both cohorts were followed for dementia until ten years after baseline. We calculated the PAR of overweight, hypertension, diabetes mellitus, cholesterol, smoking, and education. Additionally, we assessed the PAR of stroke, coronary heart disease, heart failure, and atrial fibrillation. We calculated the PAR for each risk factor separately and the combined PAR taking into account the interaction of risk factors. Results: During 57,996 person-years, 624 participants of the original cohort developed dementia, and during 26,177 person-years, 145 participants of the extended cohort developed dementia. The combined PAR in the original cohort was 0.23 (95 % CI, 0.05-0.62). The PAR in the extended cohort was slightly higher at 0.30 (95 % CI, 0.06-0.76). The combined PAR including cardiovascular diseases was 0.25 (95 % CI, 0.07-0.62) in the original cohort and 0.33 (95 % CI, 0.07-0.77) in the extended cohort. Conclusions: A substantial part of dementia cases could be prevented if modifiable risk factors would be eliminated. Although prevention and treatment options of cardiovascular risk factors and diseases have improved, the preventive potential for dementia has not declined over the last two decades. |
| Databáze: | OpenAIRE |
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