Differential transcriptome regulation by 3,5-T2 and 3′,3,5-T3 in brain and liver uncovers novel roles for thyroid hormones in tilapia
| Autor: | N. Buisine, Verónica Jiménez-Jacinto, A. Olvera, Alejandro Sanchez-Flores, L. M. Sachs, Christopher J. Martyniuk, Aurea Orozco |
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| Přispěvatelé: | Universidad Nacional Autónoma de México (UNAM), University of Florida [Gainesville] (UF), Evolution des régulations endocriniennes (ERE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2017 |
| Předmět: |
Fish Proteins
0301 basic medicine medicine.medical_specialty Cell signaling Diiodothyronines [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology lcsh:Medicine Biology Article Transcriptome 03 medical and health sciences Pleiotropy [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Internal medicine medicine Animals Cluster Analysis lcsh:Science Gene Multidisciplinary Triiodothyronine lcsh:R Brain Lipid metabolism Cell biology 030104 developmental biology Endocrinology Gene Expression Regulation Liver Nuclear receptor Organ Specificity lcsh:Q Signal Transduction Tilapia Hormone |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2017, 7, pp.15043. ⟨10.1038/s41598-017-14913-9⟩ Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-14913-9 |
| Popis: | Although 3,5,3′-triiodothyronine (T3) is considered to be the primary bioactive thyroid hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data suggest that 3,5-diiodothyronine (T2) can also regulate transcriptional networks. To determine the functional relevance of these bioactive THs, RNA-seq analysis was conducted in the cerebellum, thalamus-pituitary and liver of tilapia treated with equimolar doses of T2 or T3. We identified a total of 169, 154 and 2863 genes that were TH-responsive (FDR |
| Databáze: | OpenAIRE |
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