Metabolic effects of resistance or high-intensity interval training among glycemic control-nonresponsive children with insulin resistance
| Autor: | Mikel Izquierdo, Cristian Álvarez, Alicia M. Alonso-Martínez, Mauricio Castro-Sepulveda, Cristina Martínez, Rodrigo Ramirez-Campillo, Robinson Ramírez-Vélez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male Physiology Endocrinology Diabetes and Metabolism Glucose blood level Medicine (miscellaneous) High-Intensity Interval Training Physical strength Glucose homeostasis Procedures Body composition Interval training 0302 clinical medicine Glycemic control Controlled clinical trial Cardiovascular performance Prevalence Medicine Insulin Child Priority journal Nutrition and Dietetics Insulin blood level Waist circumference Female High-intensity interval training Human medicine.medical_specialty Waist Sedentary lifestyle 030209 endocrinology & metabolism Major clinical study Article 03 medical and health sciences Insulin resistance General condition improvement Internal medicine Blood glucose Humans Muscle Strength Exercise physiology Exercise Glycemic High intensity interval training Physical inactivity business.industry Muscle strength Abdominal fat Resistance Training 030229 sport sciences Homeostasis model assessment medicine.disease Resistance training Outcome assessment Endocrinology Blood pressure Glucose Metabolism Statistics and numerical data School child Insulin Resistance business Controlled study Analysis |
| Zdroj: | Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario |
| Popis: | Background:Little evidence exists on which variables of body composition or muscular strength mediates more glucose control improvements taking into account inter-individual metabolic variability to different modes of exercise training.Objective:We examined â mediators' to the effects of 6-weeks of resistance training (RT) or high-intensity interval training (HIT) on glucose control parameters in physically inactive schoolchildren with insulin resistance (IR). Second, we also determined both training-induce changes and the prevalence of responders (R) and non-responders (NR) to decrease the IR level.Methods:Fifty-six physically inactive children diagnosed with IR followed a RT or supervised HIT program for 6 weeks. Participants were classified based on 'HOMA-IR into glycemic control R (decrease in homeostasis model assessment-IR (HOMA-IR) less than 3.0 after intervention) and NRs (no changes or values HOMA-IR?43.0 after intervention). The primary outcome was HOMA-IR associated with their mediators; second, the training-induced changes to glucose control parameters; and third the report of R and NR to improve body composition, cardiovascular, metabolic and performance variables.Results:Mediation analysis revealed that improvements (decreases) in abdominal fat by the waist circumference can explain more the effects (decreases) of HOMA-IR in physically inactive schoolchildren under RT or HIT regimes. The same analysis showed that increased one-maximum repetition leg-extension was correlated with the change in HOMA-IR (?=0.058; P=0.049). Furthermore, a change in the waist circumference fully mediated the dose-response relationship between changes in the leg-extension strength and HOMA-IR (??=0.004; P=0.178). RT or HIT were associated with significant improvements in body composition, muscular strength, blood pressure and cardiometabolic parameters irrespective of improvement in glycemic control response. Both glucose control RT-R and HIT-R (respectively), had significant improvements in mean HOMA-IR, mean muscular strength leg-extension and mean measures of adiposity.Conclusions:The improvements in the lower body strength and the decreases in waist circumference can explain more the effects of the improvements in glucose control of IR schoolchildren in R group after 6 weeks of RT or HIT, showing both regimes similar effects on body composition or muscular strength independent of interindividual metabolic response variability. © 2018 Macmillan Publishers Limited, part of Springer Nature. |
| Databáze: | OpenAIRE |
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