Effects of Interactions among Gene Polymorphisms of the Renin–Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia
| Autor: | Aysegul Bayramoglu, Arif Suner, Meral Urhan-Kucuk, Halil Ibrahim Guler, Abdullah Arpaci, Sevim Karakas-Celik, Hasret Ecevit |
|---|---|
| Přispěvatelé: | Zonguldak Bülent Ecevit Üniversitesi, Bayramoğlu, Ayşegül |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
haplotype medicine.medical_specialty hypertension business.industry Turkish 030204 cardiovascular system & hematology renin-angiotensin-aldosterone system (RAAS) language.human_language ACE I/D 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Internal medicine Renin–angiotensin system medicine language Medicine genetic variations business Gene |
| Zdroj: | Romanian Journal of Laboratory Medicine, Vol 27, Iss 2, Pp 159-168 (2019) |
| ISSN: | 2284-5623 |
| DOI: | 10.2478/rrlm-2019-0011 |
| Popis: | WOS: 000467103000005 Introduction: Hypertension (HT) is characterized by high blood pressure. The reninangiotensin-aldosterone system (RAAS) plays a crucial role in blood pressure (BP) regulation by maintaining vascular tone and the water-sodium balance. We aimed to investigate whether there is any relation between AGT (M235T), ACE (I/D), and AGTR1 (A1166C) genetic polymorphisms and hypertension among Turkish people from Southeast Anatolia. Method and Results: A total of 210 individuals, consisting of 102 healthy controls and 108 patients with essential hypertension admitted to the Cardiology Department of the Adiyaman University Research and Application Hospital were included the study. DNA isolation was performed from the blood samples via commercial kit. Genotype determination was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Statistically significant differences were found between the control and patient groups in terms of genotype distribution and allelic frequencies of ACE I/D polymorphisms. Significant differences were found in the frequencies of ICM, DCM, DCT, DAT between the patient and control groups. Conclusions: In this study, we found a significant association of ACE I/D polymorphism with HT, and we showed that the I allele can increase the risk of HT in Turkish people from Southeast Anatolia. Although we did not find any association between independent AGT M235T and AGT1R A1166C polymorphisms and HT, we observed that the DCM, DCT, and DAT haplotypes of ACE/AGT1R/AGT polymorphisms reduced the risk of hypertension, while the ICM haplotype increased it. Research Foundation of Adiyaman UniversityAdiyaman University [TIPFBAP/2013-0004] This study was supported by a grant from the Research Foundation of Adiyaman University (TIPFBAP/2013-0004), Turkey. |
| Databáze: | OpenAIRE |
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