Performance of Finnish biobanks in nationwide pulmonary carcinoid tumour research

Autor: Caj Haglund, Elisa Lappi-Blanco, Tiina Vesterinen, Teijo Kuopio, Harri Mustonen, Kaisa Salmenkivi, Olli Carpén, Paula Vainio, Timo Paavonen, Aija Knuuttila, Johanna Arola
Přispěvatelé: HUSLAB, Institute for Molecular Medicine Finland, Department of Pathology, University of Helsinki, Helsinki Institute of Life Science HiLIFE, HUS Abdominal Center, Clinicum, Department of Surgery, Department of Medicine, Keuhkosairauksien yksikkö, HUS Heart and Lung Center, Precision Cancer Pathology, Olli Mikael Carpen / Principal Investigator, Medicum, Research Program in Systems Oncology, Research Programs Unit, II kirurgian klinikka, CAN-PRO - Translational Cancer Medicine Program, Faculty of Medicine
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Lung Neoplasms
Proliferation index
biopankit
Disease
Neuroendocrine tumors
keuhkosyöpä
Pulmonary carcinoid
Tumour tissue
0302 clinical medicine
RARE
Registries
INDEX
Finland
Biological Specimen Banks
OUTCOMES
rare cancer
SURGICAL RESECTION
General Medicine
Middle Aged
Prognosis
Biobank
3. Good health
biobank
030220 oncology & carcinogenesis
Mediastinal lymph node
SURVIVAL
Original Article
Female
BURDEN
pulmonary carcinoid
Adult
medicine.medical_specialty
3122 Cancers
Carcinoid Tumor
Pathology and Forensic Medicine
03 medical and health sciences
Internal medicine
medicine
QUALITY
Humans
harvinaiset taudit
Molecular Biology
business.industry
Rare cancer
ennusteet
Cell Biology
medicine.disease
Carcinoma
Neuroendocrine
Cancer registry
Pulmonary carcinoid tumour
030104 developmental biology
EXPERIENCE
prognosis
3111 Biomedicine
business
NEUROENDOCRINE TUMORS
Zdroj: Virchows Archiv
ISSN: 1432-2307
0945-6317
DOI: 10.1007/s00428-019-02625-6
Popis: Finnish hospital-integrated biobanks administer millions of formalin-fixed paraffin-embedded tissue samples collected within the clinical diagnostics. According to the Finnish Biobank Act, these samples can be coupled with patients’ clinical follow-up data and the data retrieved from national health registries. We collected a nationwide pulmonary carcinoid tumour series from Finnish biobanks to study prognostic factors as well as to explore how the number of tumours found in the Finnish biobanks corresponds to the number of tumours registered by the Finnish Cancer Registry (FCR). Finnish biobanks identified 88% of the tumours registered by the FCR and were able to deliver 63%. The main reasons for lacking samples were paucity of resected primary tumour tissue, incompatible primary diagnosis, and the absence of tissue blocks in the archives. The main bottleneck in the sample application process was retrieving patient data. Altogether, we received 224 tumour samples with appropriate patient data and identified six prognostic factors for shorter disease-specific survival: age over 56 years at the time of diagnosis, tumour size over 2.5 cm, atypical histology, Ki-67 proliferation index higher than 2.5%, hilar/mediastinal lymph node involvement at the time of diagnosis, and the presence of metastatic disease. In conclusion, the Finnish biobank infrastructure offers excellent opportunities for tissue-based research. However, to be able to develop the biobank operations further, involving more medical knowledge in the sample and data acquisition process is a necessity. Also, when working with tissue samples collected over decades, histological expertise is essential for re-evaluation and re-classification of the samples.
Databáze: OpenAIRE
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