Epicardial Adipose Tissue and Invasive Hemodynamics in Heart Failure With Preserved Ejection Fraction
| Autor: | Dirk J. van Veldhuisen, Elke S. Hoendermis, Michiel Rienstra, Adriaan A. Voors, Michael G. Dickinson, Gijs van Woerden, Thomas M. Gorter, Yoran M. Hummel |
|---|---|
| Přispěvatelé: | Cardiovascular Centre (CVC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Cardiac Catheterization 030204 cardiovascular system & hematology Ventricular Function Left MECHANISMS 03 medical and health sciences 0302 clinical medicine Internal medicine CARDIOMETABOLIC RISK medicine Humans 030212 general & internal medicine Pulmonary wedge pressure Aged Retrospective Studies Heart Failure Ejection fraction Exercise Tolerance business.industry Hemodynamics VO2 max Stroke Volume medicine.disease epicardial adipose tissue HFpEF exercise capacity Preload medicine.anatomical_structure Adipose Tissue Ventricle Echocardiography invasive hemodynamics FAT Heart failure Cardiology Vascular resistance Female Cardiology and Cardiovascular Medicine business Heart failure with preserved ejection fraction Pericardium |
| Zdroj: | JACC. Heart failure, 8(8), 667-676. ELSEVIER SCI LTD |
| ISSN: | 2213-1779 |
| Popis: | Objectives: This study examined associations between epicardial adipose tissue (EAT), invasive hemodynamics, and exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF). Background: EAT is increased in patients with HFpEF and may play a role in the pathophysiology of this disorder. Methods: Patients with heart failure and a left ventricular ejection fraction >45% who underwent right and left heart catheterization with simultaneous echocardiography were included. Pulmonary capillary wedge pressure (PCWP), left ventricular end-diastolic pressure (LVEDP), right ventricular end-diastolic pressure (RVEDP), and pulmonary vascular resistance (PVR) were invasively measured. Obesity was defined as body mass index (BMI) ≥30 kg/m2. EAT thickness alongside the right ventricle was measured on echocardiographic long- and short-axis views. Cardiopulmonary exercise testing was performed to obtain maximal oxygen uptake (VO2-max). Results: This study examined 75 patients, mean age 74 ± 9 years; 68% were women, mean BMI was 29 ± 6 kg/m2, and 36% were obese. Higher BMI was strongly associated with increased EAT (r = 0.74; p < 0.001). Increased EAT was associated with higher RVEDP, independent of PVR (odds ratio [OR]: 1.16; 95% confidence interval [CI]: 1.02 to 1.34; p = 0.03), but not independent of obesity (p = 0.10). Increased EAT and higher RVEDP were both associated with lower VO2-max (r = −0.43; p < 0.001 and r = −0.43; p = 0.001, respectively). Increased EAT remained associated with lower VO2-max after adjustment for PVR (OR: 0.64; 95% CI: 0.49 to 0.84; p = 0.002) and obesity (OR: 0.69; 95% CI: 0.53 to 0.92; p = 0.01). EAT thickness was not associated with left-sided filling pressures (i.e., PCWP and LVEDP). Conclusions: In HFpEF, obesity and increased EAT were associated with higher right-sided filling pressures and with reduced exercise capacity. |
| Databáze: | OpenAIRE |
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