Differential Changes in Type I And Type Ii Muscle Fibres in Rheumatoid Arthritis: A Biopsy Study
| Autor: | L. Edström, Rolf Nordemar |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty ATPase Immunology Arthritis Rheumatoid chemistry.chemical_compound Glycogen phosphorylase Atrophy Myofibrils Rheumatology Biopsy medicine Humans Immunology and Allergy NADH NADPH Oxidoreductases Aged Adenosine Triphosphatases Muscle biopsy Staining and Labeling medicine.diagnostic_test biology Glycogen Histocytochemistry business.industry Muscles Biopsy Needle General Medicine Middle Aged medicine.disease chemistry Biochemistry biology.protein Female Sudan Black B business Myofibril |
| Zdroj: | Scandinavian Journal of Rheumatology. 3:155-160 |
| ISSN: | 1502-7732 0300-9742 |
| DOI: | 10.3109/03009747409097142 |
| Popis: | Thirteen patients with classical or definite rheumatoid arthritis (RA) have been investigated by the application of a battery of histochemical staining methods on muscle biopsy material, viz. myofibrillar ATPase, modified ATPase method with acid preincubation, phosphorylase, glycogen (PAS), succinic dehydrogenase, NADH2tetrazolium reductase, fat (sudan black B). Hematoxylin-eosin stain and a modified trichrome method were also used. Based on their stainability for myofibrillar ATPase the muscle fibres are classified as type I (lightly stained) and type II (darkly stained). A preferential atrophy of type II fibres is evident. A segmental degeneration of fibres accompanied by a segmental loss of enzyme activity is found in both types of fibre. It is emphasized that the type II atrophy must be the result of a more complex mechanism than simple “disuse”. One of the cases exhibits a pronounced change in the localisation of enzymes and substrates in atrophic as well as normal-sized fibres. A reversal of normal ... |
| Databáze: | OpenAIRE |
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