Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study
| Autor: | Scott L. Rauch, Natasha B. Lasko, Paul J. Whalen, Scott P. Orr, Michael L. Macklin, Lisa M. Shin, Sean C. McInerney, Roger K. Pitman |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Automaticity behavioral disciplines and activities Amygdala Stress Disorders Post-Traumatic Neuroimaging Image Processing Computer-Assisted medicine Humans Biological Psychiatry Anterior cingulate cortex Cerebral Cortex Psychiatric Status Rating Scales Facial expression medicine.diagnostic_test Middle Aged medicine.disease Magnetic Resonance Imaging Frontal Lobe medicine.anatomical_structure Face Anxiety medicine.symptom Psychology Functional magnetic resonance imaging Neuroscience psychological phenomena and processes Anxiety disorder |
| Zdroj: | Biological Psychiatry. 47:769-776 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/s0006-3223(00)00828-3 |
| Popis: | Background: Converging lines of evidence have implicated the amygdala in the pathophysiology of posttraumatic stress disorder (PTSD). We previously developed a method for measuring automatic amygdala responses to general threat-related stimuli; in conjunction with functional magnetic resonance imaging, we used a passive viewing task involving masked presentations of human facial stimuli. Methods: We applied this method to study veterans with PTSD and a comparison cohort of combat-exposed veterans without PTSD. Results: The findings indicate that patients with PTSD exhibit exaggerated amygdala responses to masked-fearful versus masked-happy faces. Conclusions: Although some previous neuroimaging studies of PTSD have demonstrated amygdala recruitment in response to reminders of traumatic events, this represents the first evidence for exaggerated amygdala responses to general negative stimuli in PTSD. Furthermore, by using a probe that emphasizes automaticity, we provide initial evidence of amygdala hyperresponsivity dissociated from the "top-down" influences of medial frontal cortex. |
| Databáze: | OpenAIRE |
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