Development and Characterization of a Biomimetic Totally Implantable Artificial Basilar Membrane System
Autor: | Shin Hur, Jin Ho Kim, Juyong Chung, Sung June Kim, Wan Doo Kim, Youngdo Jung, Seung Ha Oh, Yun-Hoon Choung |
---|---|
Rok vydání: | 2021 |
Předmět: |
Histology
Computer science medicine.medical_treatment Biomedical Engineering Bioengineering 02 engineering and technology sensorineural 01 natural sciences basilar membrane Cochlear implant 0103 physical sciences medicine otorhinolaryngologic diseases Power output biomimetics 010301 acoustics Sound wave Original Research hearing loss cochlear implant Bioengineering and Biotechnology 021001 nanoscience & nanotechnology Basilar membrane Power consumption Biomimetics 0210 nano-technology TP248.13-248.65 Biotechnology Biomedical engineering |
Zdroj: | Frontiers in Bioengineering and Biotechnology Frontiers in Bioengineering and Biotechnology, Vol 9 (2021) |
ISSN: | 2296-4185 |
Popis: | Cochlear implants (CIs) have become the standard treatment for severe-to-profound sensorineural hearing loss. Conventional CIs have some challenges, such as the use of extracorporeal devices, and high power consumption for frequency analysis. To overcome these, artificial basilar membranes (ABMs) made of piezoelectric materials have been studied. This study aimed to verify the conceptual idea of a totally implantable ABM system. A prototype of the totally implantable system composed of the ABM developed in previous research, an electronic module (EM) for the amplification of electrical output from the ABM, and electrode was developed. We investigated the feasibility of the ABM system and obtained meaningful auditory brainstem responses of deafened guinea pigs by implanting the electrode of the ABM system. Also, an optimal method of coupling the ABM system to the human ossicle for transducing sound waves into electrical signals using the middle ear vibration was studied and the electrical signal output according to the sound stimuli was measured successfully. Although the overall power output from the ABM system is still less than the conventional CIs and further improvements to the ABM system are needed, we found a possibility of the developed ABM system as a totally implantable CIs in the future. |
Databáze: | OpenAIRE |
Externí odkaz: |