Relationship between insulin resistance, insulin secretion, very low density lipoprotein kinetics, and plasma triglyceride levels in normotriglyceridemic man
| Autor: | Fredric B. Kraemer, Gerald M. Reaven, Ted A. Tobey, Michael S. Greenfield |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male Very low-density lipoprotein medicine.medical_specialty Endocrinology Diabetes and Metabolism Glucose uptake medicine.medical_treatment Kinetics Lipoproteins VLDL chemistry.chemical_compound Endocrinology Insulin resistance Internal medicine Insulin Secretion medicine Hyperinsulinemia Humans Insulin Secretion Triglycerides Aged Triglyceride Chemistry nutritional and metabolic diseases Middle Aged medicine.disease Female Insulin Resistance |
| Zdroj: | Metabolism. 30:165-171 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(81)90167-0 |
| Popis: | We have previously postulated that resistance to insulin-mediated glucose uptake was the basic metabolic abnormality in patients with endogenous hypertriglyceridemia. In this situation, glucose tolerance would tend to deteriorate, and could only be maintained by the increased secretion of insulin. Although the ensuing hyperinsulinemia might prevent the development of glucose intolerance, we suggested that it would also lead to increased hepatic very low density (VLDL) triglyceride (TG) synthesis and secretion. In the current study we have quantified these four metabolic variables in 16 nonobese human subjects with plasma TG concentrations less than 175 mg/dl. The results demonstrate the following degree of correlation: insulin resistance (Formula: see text) insulin response to food (Formula: see text) VLDL-TG secretion rate (Formula: see text) plasma TG concentration. These data indicate that nonobese subjects with normal TG levels have the same relationship between degree of insulin sensitivity, insulin response to food, VLDL-TG secretion, and TG concentration previously described in patients with endogenous hypertriglyceridemia. |
| Databáze: | OpenAIRE |
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