Biologically effective dose correlates with linear tumour volume changes after upfront single-fraction stereotactic radiosurgery for vestibular schwannomas
| Autor: | Constantin Tuleasca, Mohamed Faouzi, Raphael Maire, Philippe Maeder, Jonathan P.S. Knisely, Marc Levivier |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Gamma knife Radiosurgery Effective dose (radiation) 030218 nuclear medicine & medical imaging Biologically effective dose 03 medical and health sciences 0302 clinical medicine Vestibular schwannoma Linear regression Humans Medicine Grading (tumors) Retrospective Studies Tumor business.industry Gamma Knife Volume Neuroma Acoustic General Medicine Tumor Burden Treatment Outcome Vestibular Schwannomas Neuroma Acoustic/radiotherapy Neuroma Acoustic/surgery Switzerland Original Article Surgery Neurosurgery Neurology (clinical) business Nuclear medicine 030217 neurology & neurosurgery Follow-Up Studies Volume (compression) |
| Zdroj: | Neurosurgical Review Neurosurgical review, vol. 44, no. 6, pp. 3527-3537 |
| ISSN: | 1437-2320 |
| DOI: | 10.1007/s10143-022-01769-5 |
| Popis: | Vestibular schwannomas (VSs) are benign, slow-growing tumors. Management options include observation, surgery, and radiation. In this retrospective trial, we aimed at evaluating whether biologically effective dose (BED) plays a role in tumor volume changes after single-fraction first intention stereotactic radiosurgery (SRS) for VS. We compiled a single-institution experience (n = 159, Lausanne University Hospital, Switzerland). The indication for SRS was decided after multidisciplinary discussion. Only cases with minimum 3 years follow-up were included. The Koos grading, a reliable method for tumor classification was used. Radiosurgery was performed using Gamma Knife (GK) and a uniform marginal prescription dose of 12 Gy. Mean BED was 66.3 Gy (standard deviation 3.8, range 54.1–73.9). The mean follow-up period was 5.1 years (standard deviation 1.7, range 3–9.2). The primary outcome was changes in 3D volumes after SRS as function of BED and of integral dose received by the VS. Random-effect linear regression model showed that tumor volume significantly and linearly decreased over time with higher BED (p p |
| Databáze: | OpenAIRE |
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