Age-associated increases in heme oxygenase-1 and ferritin immunoreactivity in the autopsied brain
| Autor: | Wataru Hirose, Ryouichi Tsuda, Kazuya Ikematsu |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Aging medicine.medical_specialty Pathology Adolescent Traumatic brain injury Hippocampus Pathology and Forensic Medicine chemistry.chemical_compound Parietal Lobe Internal medicine Heat shock protein medicine Humans Child Heme Aged Aged 80 and over biology Membrane Proteins Human brain Middle Aged medicine.disease Immunohistochemistry Ferritin Heme oxygenase Issues ethics and legal aspects Endocrinology medicine.anatomical_structure chemistry Cerebral cortex Child Preschool Ferritins Heme Oxygenase (Decyclizing) biology.protein Occipital Lobe Heme Oxygenase-1 |
| Zdroj: | Legal Medicine. 5:S360-S366 |
| ISSN: | 1344-6223 |
| DOI: | 10.1016/s1344-6223(02)00133-5 |
| Popis: | Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain. Furthermore, the release of free ferrous ion by HO-1 plays an essential role in ferritin synthesis, and ferritin stores iron either for intracellular utilization, or for detoxification. It is well known that HO-1 immunoreactivity is enhanced greatly in neurons and glia of the hippocampus and cerebral cortex in various pathophysiological conditions. The expression of HSP 70 is well known for the age-associated increase, but the expression modalities of HO-1 and ferritin associated with aging are still unknown. A study was therefore performed to examine the correlations in the expression of HO-1 and ferritin with age using immunohistochemistry. We investigated 31 autopsied brains (3-84-year-olds) without traumatic brain injury and neurodegenerative disease. The specimens were taken from the cerebral cortex and hippocampus. In the cerebral cortex, age (aging) had a statistically significant positive correlation with HO-1 (r=0.894, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect