Regulation of primary response and specific genes in adrenal cells by peptide hormones and growth factors

Autor: José M. Saez, Armelle Penhoat, Dominique Langlois, R. Ouali, I. Viard
Přispěvatelé: Communications Cellulaires et Différenciation (CCD), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), ProdInra, Migration
Jazyk: angličtina
Rok vydání: 1996
Předmět:
[SDV]Life Sciences [q-bio]
Clinical Biochemistry
Drug Resistance
Biochemistry
Proto-Oncogene Mas
0302 clinical medicine
Endocrinology
Transforming Growth Factor beta
Insulin-Like Growth Factor I
Growth Substances
Cells
Cultured
ComputingMilieux_MISCELLANEOUS
0303 health sciences
Receptors
Angiotensin
biology
Adrenal cortex
Angiotensin II
Cell Differentiation
TGF
Gene Expression Regulation
Neoplastic
[SDV] Life Sciences [q-bio]
medicine.anatomical_structure
hormones
hormone substitutes
and hormone antagonists
Zona reticularis
endocrine system
medicine.medical_specialty
030209 endocrinology & metabolism
Adrenocorticotropic hormone
Peptide hormone
03 medical and health sciences
Zona fasciculata
Adrenocorticotropic Hormone
Internal medicine
Proto-Oncogenes
medicine
Animals
Humans
ACTH receptor
RNA
Messenger
Molecular Biology
TGF beta 1
030304 developmental biology
Pharmacology
SURRENALE
Organic Chemistry
Transforming growth factor beta
Zona Reticularis
Receptors
Corticotropin
biology.protein
Adrenal Cortex
Cattle
Zona Fasciculata
Zdroj: Steroids
Steroids, Elsevier, 1996, 61, pp.176-183
ISSN: 0039-128X
Popis: Using cultured bovine adrenal fasciculata cells (BAC), we investigated the effects of two hormones, corticotropin (ACTH) and angiotensin II (Ang-II) and two growth factors, insulin-like growth factors I (IGF-I) and transforming growth factor beta 1 (TGF beta 1), on the mRNA levels of nuclear proto-oncogenes of the Fos and Jun families and on the mRNA levels of genes expressed in BAC coding for ACTH and AT1 receptors, cytochrome P450scc and P450 17 alpha and 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD). ACTH and IGF-1 increased c-fos and jun-B mRNA levels early with later increases in the levels of mRNA for the ACTH receptor and the three steroidogenic enzymes, and enhanced steroidogenic responses to both ACTH and Ang-II. In contrast, Ang-II increased mRNA coding for the three proto-oncogenes (cfos, c-jun, and jun-B), decreased those for P450 17 alpha and 3 beta-HSD, and caused marked homologous and heterologous steroidogenic desensitization. TGF beta 1 increased only jun-B mRNA and markedly reduced BAC-differentiated functions and steroidogenic responsiveness to both ACTH and Ang-II. The long-term effects of ACTH on human adrenal fasciculata cells were comparable with those observed in BAC, whereas the long term effects of Ang-II and TGF beta 1 were different from those observed in BAC. Whether these species-specific differences are related to a different effect of these factors on proto-oncogene expression is not yet known.
Databáze: OpenAIRE
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