Dietary glycaemic index, glycaemic load and endometrial and ovarian cancer risk: a systematic review and meta-analysis
| Autor: | Marie M. Cantwell, Christopher Cardwell, Liam J. Murray, Helen G. Mulholland |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Oncology
Blood Glucose Cancer Research medicine.medical_specialty MEDLINE Glycaemic index Dietary Sucrose Risk Factors Internal medicine Clinical Studies medicine Humans Risk factor Gynecology Ovarian Neoplasms business.industry Endometrial cancer Cancer medicine.disease Endometrial Neoplasms meta-analysis ovarian cancer glycaemic index Meta-analysis endometrial cancer Female Ovarian cancer business Body mass index glycaemic load |
| Zdroj: | British Journal of Cancer Mulholland, H G, Murray, L J, Cardwell, C R & Cantwell, M M 2008, ' Dietary glycaemic index, glycaemic load and endometrial and ovarian cancer risk: a systematic review and meta-analysis. ' British Journal of Cancer, vol 99, no. 3, pp. 434-441 . DOI: 10.1038/sj.bjc.6604496 |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Long-term consumption of a high glycaemic index (GI) or glycaemic load (GL) diet may lead to chronic hyperinsulinaemia, which is a potential risk factor for cancer. To date, many studies have examined the association between GI, GL and cancer risk, although results have been inconsistent, therefore our objective was to conduct a systematic review of the literature. Medline and Embase were systematically searched using terms for GI, GL and cancer to identify studies published before December 2007. Random effects meta-analyses were performed for endometrial cancer, combining maximally adjusted results that compared risk for those in the highest versus the lowest category of intake. Separate analysis examined risk by body mass index categories. Five studies examining GI and/or GL intake and endometrial cancer risk were identified. Pooled effect estimates for endometrial cancer showed an increased risk for high GL consumers (RR 1.20; 95% CI: 1.06-1.37), further elevated in obese women (RR 1.54; 95% CI: 1.18-2.03). No significant associations were observed for GI. Only two studies examined ovarian cancer and therefore no meta-analysis was performed, but results indicate positive associations for GL also. A high GL, but not a high GI, diet is positively associated with the risk of endometrial cancer, particularly among obese women. © 2008 Cancer Research UK All rights reserved. |
| Databáze: | OpenAIRE |
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