Synthesis and antimycobacterial activities of glycosylated amino alcohols and amines
| Autor: | Saroj Verma, R.P. Tripathi, R. Srivastava, Anil N. Gaikwad, Brahm S. Srivastava, Neetu Tewari, Sudhir Sinha, Vinod K. Tiwari, Diksha Katiyar, Vinita Chaturvedi, A. K. Srivastava |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pharmacology
Glycosylation Molecular Structure Chemistry medicine.drug_class Organic Chemistry General Medicine Antimycobacterial Amino Alcohols Reductive amination Chemical synthesis Anti-Bacterial Agents Mycobacterium carbohydrates (lipids) Sodium borohydride chemistry.chemical_compound Drug Discovery medicine Organic chemistry Amine gas treating Glycosyl Amines Amination Antibacterial agent |
| Zdroj: | European Journal of Medicinal Chemistry. 40:351-360 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2004.12.002 |
| Popis: | Reduction of glycosyl β-amino esters (6–14 and 25–30) with lithium aluminum hydride resulted in glycosyl amino alcohols (15–23 and 31–36) in good yields. However, reductive amination of glycosyl aldehydes (1–3) with different amines in presence of sodium borohydride resulted in good to moderate yields of glycosyl amines (37–41). All the compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv. Compounds 18, 21, 35 and 36 exhibited antitubercular activities with MIC ranging from 6.25 to 3.12 μg ml–1. |
| Databáze: | OpenAIRE |
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