Association of Trp64Arg Polymorphism of β3-Adrenergic Receptor with Insulin Resistance in Polish Children with Obesity
| Autor: | Renata Stawerska, Katarzyna Cypryk, Andrzej Lewiński, Małgorzata Zawodniak-Szałapska, Dorota Pastuszak-Lewandoska, Ewa Brzeziańska, Jolanta Lukamowicz |
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| Rok vydání: | 2008 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Adolescent Genotype Adrenergic receptor Endocrinology Diabetes and Metabolism medicine.medical_treatment Susceptibility gene Body Mass Index Endocrinology Insulin resistance Internal medicine medicine Humans Insulin Obesity Oral glucose tolerance Child Receptor Triglycerides Polymorphism Genetic business.industry nutritional and metabolic diseases Glucose Tolerance Test medicine.disease Lipids Receptors Adrenergic beta-3 Mutation Pediatrics Perinatology and Child Health Female Poland Insulin Resistance business Body mass index |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 21 |
| ISSN: | 2191-0251 0334-018X |
| Popis: | AIM To establish the influence of the Trp64Arg variant of the beta3-adrenergic receptor (Trp64Arg- beta3AR) on body mass index (BMI) and insulin resistance (IR) in obese children. METHODS BMI, presence of the Trp64Arg mutation, plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT) and IR were determined in 60 obese and 33 normal weight children. RESULTS The frequency of Trp64Arg was similar in normal weight and obese children. BMI, glucose and insulin concentrations during an OGTT in children with Trp64Argbeta3AR were not different from those with Trp64Trpbeta3AR. IR was confirmed in 42.8% of children with Trp64Argbeta3AR and in 45.6% of children with Trp64Trpbeta3AR (NS). CONCLUSIONS 1. The similar frequency of the Trp64Argbeta3AR variant in normal weight and obese children suggests that it is not a susceptibility gene for obesity in Polish children. 2. The presence of the Trp64Argbeta3AR variant does not have an unfavourable influence on BMI, glucose or insulin concentrations during OGTT or on IR frequency in Polish obese children. |
| Databáze: | OpenAIRE |
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