Utility of C-peptide for a reliable estimate of insulin secretion in children with growth hormone deficiency
| Autor: | S. Radellini, F. Cicciò, Carla Giordano, Alessandro Ciresi |
|---|---|
| Přispěvatelé: | Ciresi, A., Cicciò, F., Radellini, S., Giordano, C. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Biology Glucagon Hypopituitarism Growth hormone deficiency Settore MED/13 - Endocrinologia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Insulin resistance Insulin-Secreting Cells Diabetes mellitus Internal medicine Insulin Secretion medicine Humans Insulin C-peptide growth hormone deficiency Prospective Studies Insulin-Like Growth Factor I Child Glucose tolerance test C-Peptide medicine.diagnostic_test Human Growth Hormone C-peptide Fasting Glucose Tolerance Test medicine.disease Hormones Growth hormone treatment 030104 developmental biology chemistry Area Under Curve Case-Control Studies Child Preschool Female Insulin Resistance |
| Popis: | OBJECTIVE: GH treatment (GHT) can lead to glucose metabolism impairment through decreased insulin sensitivity and impaired pancreatic β-cell function, which are the two key components of the pathogenesis of diabetes. Therefore, in addition to insulin sensitivity, during GHT it is very important to perform a reliable evaluation of insulin secretion. However, conflicting data exist regarding the insulin secretion in children during GHT. C-peptide provides a more reliable estimate of β-cell function than insulin, but few studies evaluated it during GHT. Our aim was to assess the usefulness of C-peptide in the evaluation of insulin secretion in GH deficiency (GHD) children. DESIGN: In 48 GHD children, at baseline and after 12 and 24months of GHT, and in 56 healthy subjects we evaluated fasting and glucagon-stimulated (AUCCpep) C-peptide levels in addition to other commonly used secretion indexes, such as fasting and oral glucose tolerance test-stimulated insulin levels (AUCINS), Homa-β, and insulinogenic index. The main outcomes were the change in C-peptide during GHT and its correlation with the auxological and hormonal parameters. RESULTS: At baseline GHD children showed a significant lower AUCCpep (p=0.006), while no difference was found for the other indexes. Both fasting C-peptide (beta 0.307, p=0.016) and AUCCpep (beta 0.379, p=0.002) were independently correlated with IGF-I SDS, while no correlation was found for all other indexes. After 12months an increase in Homa-β (p |
| Databáze: | OpenAIRE |
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