The Value of Older Donors’ Klotho Level in Predicting Recipients’ Short-Term Renal Function
| Autor: | Dong Liu, Juan Ma, Jiaqing Wu, Jiexue Zhou, Anli Yang, Jianfu Wang, Sheng Shen, Gengguo Deng, Shandong Meng, Chunli Zhu |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Graft Rejection Male 0301 basic medicine Aging medicine.medical_specialty Urinary system 030232 urology & nephrology Urology Renal function Kidney urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Clinical Research Living Donors Humans Medicine Klotho Proteins Klotho Kidney transplantation Glucuronidase Retrospective Studies Receiver operating characteristic business.industry Graft Survival Age Factors Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Kidney Transplantation Tissue Donors Fibroblast Growth Factor-23 030104 developmental biology medicine.anatomical_structure Immunohistochemistry Female Biological Markers business Biomarkers |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.913274 |
| Popis: | BACKGROUND The present organ shortage has led to increased use of kidneys from expanded-criteria donors, but the prognosis is disappointing due to poor graft quality. As a promising kidney protector, the Klotho gene's role in predicting short-term prognosis has not been assessed. MATERIAL AND METHODS We retrospectively analyzed data from 41 recipients and 25 donors. Multiple clinical variables were compared between different subgroups of donors or their corresponding recipients. The area under the receiver operating characteristic curve (AUROC) was used to evaluate the distinguishing ability. Dynamic changes in serum Klotho, FGF-23, and urinary NGAL were assessed. RESULTS Serum Klotho level was significantly lower in donors age ≥50 years (p=0.017), and there was a moderate negative correlation between serum Klotho expression and age (r=-0.464, p=0.019). Moreover, detection of Klotho mRNA and immunohistochemical analysis in kidneys revealed the same trend as in serum. Furthermore, for older donors (age ≥50 years), serum Klotho level had a strong negative correlation with recipient eGFR 1 month post-transplant (r=-0.686, p=0.007), which was proved to be a good predictor for estimating graft function by ROC analysis. Additionally, during the post-transplant follow-up, serum Klotho levels increased slightly after a temporary decline, while serum FGF-23 and urinary NGAL decreased significantly and then stayed low thereafter. CONCLUSIONS Klotho level, which decreases with age, may be a potential predictor of short-term renal function, especially for grafts from older donors. |
| Databáze: | OpenAIRE |
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