2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists

Autor:	David C. Budd, David Bryan Harrison, Christopher Walker, Lucy Barker, Morris Tweed, Brian Everatt, Louise Bidlake, Rowan Stringer, Clive Aldcroft, Gurdip Bhalay, Catherine Leblanc, Emma Michelle Campbell, Urs Baettig, Simon J. Watson, Rachael Profit, Jennifer Willis, Gareth Williams, David Beer, Katharine L. Turner, Steven Whitebread, Zarin Brown, David Andrew Sandham, Gerald Dubois, Jodie Manini, Katy S Thompson, Brian Cox, Caroline Wilson
Rok vydání:	2007
Předmět:	medicine.drug_class High-throughput screening Clinical Biochemistry Receptors Prostaglandin Pharmaceutical Science Biological Availability Acetates Biochemistry Chemical synthesis Structure-Activity Relationship Oral administration Drug Discovery medicine Potency Animals Humans Receptors Immunologic Receptor Molecular Biology Chemistry Organic Chemistry Antagonist Receptor antagonist Bioavailability Rats Eosinophils Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 17(15)
ISSN:	0960-894X
Popis:	High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6368f8bff73f2b501c96315902c5c8fa https://pubmed.ncbi.nlm.nih.gov/17531480 Zobrazit plný text záznamu Full Text from ScienceDirect