Spatial and Temporal Control Over Multilayer Bio‐Polymer Film Assembly and Composition
| Autor: | Neil MacKinnon, Lorenzo Bordonali, Vlad Badilita, Nurdiana Nordin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Fabrication Polymers and Plastics Bioengineering Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials Chitosan chemistry.chemical_compound Stack (abstract data type) Lab-On-A-Chip Devices Materials Chemistry Throughput (business) chemistry.chemical_classification Process (computing) Hydrogels Membranes Artificial Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry 0210 nano-technology Layer (electronics) Biosensor Biotechnology |
| Zdroj: | Macromolecular Bioscience. 19:1800372 |
| ISSN: | 1616-5195 1616-5187 |
| Popis: | Biosensing applications have taken advantage of lab-on-a-chip technologies for sample handling and sensors integration for highly sensitive, specific detection with high throughput. These systems are based on 2.5D fabrication principles with sensing elements restricted to an array format in two dimensions. In this report, a sensing platform that recovers biosensing capabilites in three spatial dimensions is presented. This is achieved by leveraging chitosan, a stimulus responsive polyaminosaccharide that undergoes a sol-gel transition driven by a change of pH. This process can be repeated, resulting in a multilayered hydrogel stack where each layer carries a unique chemical identity. In addition, the functionality of chitosan can be modified prior to or during the assembly process. This is demonstrated by introducing both a carboxylic acid functionality and additional primary amines to the base chitosan polymer. The assembly process is shown to be compatible with microfluidic dimensions. |
| Databáze: | OpenAIRE |
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