The Hsp90 inhibitor 17-DMAG decreases infection of porcine circovirus type 2 in mice
| Autor: | Ping Jiang, Jinwei You, Min Dong, Xuliang Zhang, Li Chen, Chang Ma, Shifeng Yun, Jie Liu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Circovirus
0301 basic medicine 040301 veterinary sciences Lactams Macrocyclic animal diseases medicine.medical_treatment Interleukin-1beta Intraperitoneal injection Antibodies Viral Virus Replication Antiviral Agents Microbiology 0403 veterinary science Mice 03 medical and health sciences Immune system Benzoquinones medicine Animals HSP90 Heat-Shock Proteins Circoviridae Infections Mice Inbred BALB C biology Tumor Necrosis Factor-alpha Body Weight virus diseases Interleukin 04 agricultural and veterinary sciences Viral Load biology.organism_classification Interleukin-10 Disease Models Animal Interleukin 10 Porcine circovirus 030104 developmental biology Infectious Diseases Immunology Cytokines Female Tumor necrosis factor alpha Viral load Injections Intraperitoneal Spleen |
| Zdroj: | Microbial Pathogenesis. 109:248-252 |
| ISSN: | 0882-4010 |
| DOI: | 10.1016/j.micpath.2017.06.007 |
| Popis: | Although several factors affecting porcine circovirus type 2 (PCV2) infection have been reported, their precise roles are far from clear. The aim of this study was to determine whether 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), an inhibitor of Hsp90, could significantly affect PCV2 infection and immune responses in BALB/c mice. Intraperitoneal injection of 17-DMAG significantly reduced viral loads in the blood and tissues of mice infected with PCV2, compared with control groups. The 17-DMAG treatment decreased serum interleukin (IL)-10 and tumor necrosis factor(TNF)-α levels, but it did not have a significant effect on the IL-1β level. These data demonstrate that 17-DMAG is highly effective in suppressing PCV2 replication in BALB/c mice, indicating that it has potential value as an antiviral drug against PCV2 infection. |
| Databáze: | OpenAIRE |
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